DegronMD

Uniprot ID: Q9BVN2

Source protein: AP-4 complex accessory subunit RUSC1

Source gene: RUSC1

Class: DEG_SCF_TRCP1_1

Location: 274:279

E3 ligase: BTRC

DEGRON score: 0.992

ASA_SCORE: 76.45

COIL: 0.9065

CONS_SCORE: 0.4607

DSS_SCORE: 0.5478

HELIX: 0.0627

FCONS_SCORE: 1.134

RIG_SCORE: 0.7215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S275C	TCGA-BT-A20U	BLCA	TCGA	DSGWKT	DEG_SCF_TRCP1_1	0.7541
p.S275C	DO538	BLCA	ICGC	DSGWKT	DEG_SCF_TRCP1_1	0.7541
p.D274G	TCGA-CG-5721	STAD	TCGA	DSGWKT	DEG_SCF_TRCP1_1	0.7198
p.D274G	DO38192	STAD	ICGC	DSGWKT	DEG_SCF_TRCP1_1	0.7198
p.P270H	TCGA-D1-A15X	UCEC	TCGA	DSGWKT	DEG_SCF_TRCP1_1	0.2222
p.P270H	DO43274	UCEC	ICGC	DSGWKT	DEG_SCF_TRCP1_1	0.2222
p.K267T	TCGA-EY-A1GD	UCEC	TCGA	DSGWKT	DEG_SCF_TRCP1_1	0.25
p.K267T	DO42129	UCEC	ICGC	DSGWKT	DEG_SCF_TRCP1_1	0.25
p.S275P	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGWKT	DEG_SCF_TRCP1_1	0.6752
p.S275P	ACH-001498	Lymphoma	CCLE	DSGWKT	DEG_SCF_TRCP1_1	0.6752
p.S275P	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	0.6752
p.G264C	CAPAN-1	pancreas	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	0.0556
p.Q266L	Ca-Ski	cervix	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	0.1111
p.T281I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVN2	AP-4 complex accessory subunit RUSC1	DEG_SCF_TRCP1_1	274:279	DSGWKT	BTRC	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons