DegronMD

Uniprot ID: Q5HYK7

Source protein: SH3 domain-containing protein 19

Source gene: SH3D19

Class: DEG_SCF_TRCP1_1

Location: 651:656

E3 ligase: BTRC

DEGRON score: 0.8823

ASA_SCORE: 79.4833

COIL: 0.9412

CONS_SCORE: 0.3538

DSS_SCORE: 0.5152

HELIX: 0.0442

FCONS_SCORE: 0.9608

RIG_SCORE: 0.6168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E664K	TCGA-17-Z028	LUAD	TCGA	DSGSNS	DEG_SCF_TRCP1_1	0.1111
p.S652F	TCGA-AX-A2HC	UCEC	TCGA	DSGSNS	DEG_SCF_TRCP1_1	0.7982
p.S652F	DO41572	UCEC	ICGC	DSGSNS	DEG_SCF_TRCP1_1	0.7982
p.S656F	TCGA-DA-A1IC	SKCM	TCGA	DSGSNS	DEG_SCF_TRCP1_1	0.7982
p.S656F	DO37430	SKCM	ICGC	DSGSNS	DEG_SCF_TRCP1_1	0.7982
p.S656Y	TCGA-EO-A3B0	UCEC	TCGA	DSGSNS	DEG_SCF_TRCP1_1	0.712
p.S656Y	DO219773	UCEC	ICGC	DSGSNS	DEG_SCF_TRCP1_1	0.712
p.T647N	DO229027	LICA	ICGC	DSGSNS	DEG_SCF_TRCP1_1	0.2222
p.Q657H	SIDM00334	Endometrial Carcinoma	GDSC	DSGSNS	DEG_SCF_TRCP1_1	0.3056
p.Q657H	MFE-296	endometrium	COSMIC	DSGSNS	DEG_SCF_TRCP1_1	0.3056
p.G662A	HOS	bone	COSMIC	DSGSNS	DEG_SCF_TRCP1_1	0.1667
p.K656T	HCC2998	large_intestine	COSMIC	DSGSNS	DEG_SCF_TRCP1_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYK7	SH3 domain-containing protein 19	DEG_SCF_TRCP1_1	651:656	DSGSNS	BTRC	0.8823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons