DegronMD - Q5HYK7(SH3D19)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E664K	TCGA-17-Z028	LUAD	TCGA	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation rewiring degron network	0.1111
p.S652F	TCGA-AX-A2HC	UCEC	TCGA	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation altering degron motif	0.7982
p.S652F	DO41572	UCEC	ICGC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation altering degron motif	0.7982
p.G462C	TCGA-B5-A1MX	UCEC	TCGA	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6489
p.G462C	DO41999	UCEC	ICGC	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6489
p.E454D	TCGA-BT-A20O	BLCA	TCGA	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1111
p.E454D	DO460	BLCA	ICGC	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1111
p.S656F	TCGA-DA-A1IC	SKCM	TCGA	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation altering degron motif	0.7982
p.S656F	DO37430	SKCM	ICGC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation altering degron motif	0.7982
p.E127D	TCGA-DK-AA6S	BLCA	TCGA	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation altering degron motif	0.5647
p.E127D	DO219007	BLCA	ICGC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation altering degron motif	0.5647
p.S128R	TCGA-DX-A6YT	SARC	TCGA	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation altering degron motif	0.7427
p.S128R	DO220007	SARC	ICGC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation altering degron motif	0.7427
p.S656Y	TCGA-EO-A3B0	UCEC	TCGA	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation altering degron motif	0.712
p.S656Y	DO219773	UCEC	ICGC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation altering degron motif	0.712
p.R480T	TCGA-Q1-A73O	CESC	TCGA	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.0556
p.R480T	TCGA-Q1-A73O	CESC	TCGA	IITPLDE	DEG_SCF_FBW7_2	471:477	Mutation rewiring degron network	0.25
p.R480T	DO51612	CESC	ICGC	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.0556
p.R480T	DO51612	CESC	ICGC	IITPLDE	DEG_SCF_FBW7_2	471:477	Mutation rewiring degron network	0.25
p.P140L	DO234459	ESAD	ICGC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.2778
p.G121A	DO228950	LICA	ICGC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.1667
p.T647N	DO229027	LICA	ICGC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation rewiring degron network	0.2222
p.S129A	DO231902	LINC	ICGC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation altering degron motif	0.6477
p.H465R	SIDM00437	Acute Myeloid Leukemia	GDSC	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7133
p.Q657H	SIDM00334	Endometrial Carcinoma	GDSC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation rewiring degron network	0.3056
p.Q657H	MFE-296	endometrium	COSMIC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation rewiring degron network	0.3056
p.A126T	SIDM00945	Colorectal Carcinoma	GDSC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.A126T	ACH-000895	Colon/Colorectal Cancer	CCLE	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.A126T	CL-34	large intestine	COSMIC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.3056
p.R141Q	SIDM01617	Endometrial Carcinoma	GDSC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.25
p.R141Q	SIDM01470	Acute Myeloid Leukemia	GDSC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.25
p.R141Q	SIDM01368	Gastric Carcinoma	GDSC	ESSDSGKKVPTP	DEG_COP1_1	127:138	Mutation rewiring degron network	0.25
p.G662A	HOS	bone	COSMIC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation rewiring degron network	0.1667
p.D484N	SNU-1040	large intestine	COSMIC	IITPLDE	DEG_SCF_FBW7_2	471:477	Mutation rewiring degron network	0.1389
p.E461A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	GRVHLSQMK	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.3056
p.E461A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	IITPLDE	DEG_SCF_FBW7_2	471:477	Mutation rewiring degron network	0.0556
p.K656T	HCC2998	large intestine	COSMIC	DSGSNS	DEG_SCF_TRCP1_1	651:656	Mutation altering degron motif	0.7306

Kaplan plot for SH3D19 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3D19

UniProt ID: Q5HYK7

Entrez ID: 152503

Protein name: SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SH3D19 in