DegronMD

Uniprot ID: Q5HYK7

Source protein: SH3 domain-containing protein 19

Source gene: SH3D19

Class: DEG_APCC_DBOX_1

Location: 462:470

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.931

ASA_SCORE: 67.1889

COIL: 0.448

CONS_SCORE: 0.4727

DSS_SCORE: 0.4657

HELIX: 0.1361

FCONS_SCORE: 1.1988

RIG_SCORE: 0.764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G462C	TCGA-B5-A1MX	UCEC	TCGA	GRVHLSQMK	DEG_APCC_DBOX_1	0.6489
p.G462C	DO41999	UCEC	ICGC	GRVHLSQMK	DEG_APCC_DBOX_1	0.6489
p.E454D	TCGA-BT-A20O	BLCA	TCGA	GRVHLSQMK	DEG_APCC_DBOX_1	0.1111
p.E454D	DO460	BLCA	ICGC	GRVHLSQMK	DEG_APCC_DBOX_1	0.1111
p.R480T	TCGA-Q1-A73O	CESC	TCGA	GRVHLSQMK	DEG_APCC_DBOX_1	0.0556
p.R480T	DO51612	CESC	ICGC	GRVHLSQMK	DEG_APCC_DBOX_1	0.0556
p.H465R	SIDM00437	Acute Myeloid Leukemia	GDSC	GRVHLSQMK	DEG_APCC_DBOX_1	0.7133
p.E461A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	GRVHLSQMK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYK7	SH3 domain-containing protein 19	DEG_APCC_DBOX_1	462:470	GRVHLSQMK	APC,CDC20,FZR1	0.931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons