DegronMD

Uniprot ID: Q5HYK7

Source protein: SH3 domain-containing protein 19

Source gene: SH3D19

Class: DEG_SCF_FBW7_2

Location: 471:477

E3 ligase: FBXW7

DEGRON score: 0.8891

ASA_SCORE: 69.9143

COIL: 0.5887

CONS_SCORE: 0.3954

DSS_SCORE: 0.5551

HELIX: 0.1256

FCONS_SCORE: 1.0083

RIG_SCORE: 0.7637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R480T	TCGA-Q1-A73O	CESC	TCGA	IITPLDE	DEG_SCF_FBW7_2	0.25
p.R480T	DO51612	CESC	ICGC	IITPLDE	DEG_SCF_FBW7_2	0.25
p.D484N	SNU-1040	large_intestine	COSMIC	IITPLDE	DEG_SCF_FBW7_2	0.1389
p.E461A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IITPLDE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYK7	SH3 domain-containing protein 19	DEG_SCF_FBW7_2	471:477	IITPLDE	FBXW7	0.8891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons