DegronMD

Uniprot ID: Q5HYK7

Source protein: SH3 domain-containing protein 19

Source gene: SH3D19

Class: DEG_COP1_1

Location: 127:138

E3 ligase: COP1

DEGRON score: 0.972

ASA_SCORE: 88.2833

COIL: 0.9191

CONS_SCORE: 0.3737

DSS_SCORE: 0.6786

HELIX: 0.0278

FCONS_SCORE: 1.054

RIG_SCORE: 0.5892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E127D	TCGA-DK-AA6S	BLCA	TCGA	ESSDSGKKVPTP	DEG_COP1_1	0.5647
p.E127D	DO219007	BLCA	ICGC	ESSDSGKKVPTP	DEG_COP1_1	0.5647
p.S128R	TCGA-DX-A6YT	SARC	TCGA	ESSDSGKKVPTP	DEG_COP1_1	0.7427
p.S128R	DO220007	SARC	ICGC	ESSDSGKKVPTP	DEG_COP1_1	0.7427
p.P140L	DO234459	ESAD	ICGC	ESSDSGKKVPTP	DEG_COP1_1	0.2778
p.G121A	DO228950	LICA	ICGC	ESSDSGKKVPTP	DEG_COP1_1	0.1667
p.S129A	DO231902	LINC	ICGC	ESSDSGKKVPTP	DEG_COP1_1	0.6477
p.A126T	SIDM00945	Colorectal Carcinoma	GDSC	ESSDSGKKVPTP	DEG_COP1_1	0.3056
p.A126T	ACH-000895	Colon/Colorectal Cancer	CCLE	ESSDSGKKVPTP	DEG_COP1_1	0.3056
p.A126T	CL-34	large_intestine	COSMIC	ESSDSGKKVPTP	DEG_COP1_1	0.3056
p.R141Q	SIDM01617	Endometrial Carcinoma	GDSC	ESSDSGKKVPTP	DEG_COP1_1	0.25
p.R141Q	SIDM01470	Acute Myeloid Leukemia	GDSC	ESSDSGKKVPTP	DEG_COP1_1	0.25
p.R141Q	SIDM01368	Gastric Carcinoma	GDSC	ESSDSGKKVPTP	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYK7	SH3 domain-containing protein 19	DEG_COP1_1	127:138	ESSDSGKKVPTP	COP1	0.972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons