DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_COP1_1

Location: 622:631

E3 ligase: COP1

DEGRON score: 0.9928

ASA_SCORE: 88.37

COIL: 0.9351

CONS_SCORE: 0.3374

DSS_SCORE: 0.4439

HELIX: 0.0344

FCONS_SCORE: 1.0459

RIG_SCORE: 0.6818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P634L	TCGA-32-2616	GBM	TCGA	DSGSQAVPSP	DEG_COP1_1	0.25
p.R639Q	TCGA-A5-A2K5	UCEC	TCGA	DSGSQAVPSP	DEG_COP1_1	0.5556
p.R639Q	SIDM00683	Prostate Carcinoma	GDSC	DSGSQAVPSP	DEG_COP1_1	0.5556
p.R639Q	LNCaP-Clone-FGC	prostate	COSMIC	DSGSQAVPSP	DEG_COP1_1	0.5556
p.S640F	TCGA-AO-A03M	BRCA	TCGA	DSGSQAVPSP	DEG_COP1_1	0.5278
p.S635F	DO2216	BRCA	ICGC	DSGSQAVPSP	DEG_COP1_1	0.6667
p.P629L	DO13462	GBM	ICGC	DSGSQAVPSP	DEG_COP1_1	0.7582
p.R634Q	DO41379	UCEC	ICGC	DSGSQAVPSP	DEG_COP1_1	0.25
p.R634Q	LNCaP-Clone-FGC	prostate	COSMIC	DSGSQAVPSP	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_COP1_1	622:631	DSGSQAVPSP	COP1	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons