DegronMD

Uniprot ID: Q9P2Q2

Source protein: FERM domain-containing protein 4A

Source gene: FRMD4A

Class: DEG_SCF_TRCP1_1

Location: 954:960

E3 ligase: BTRC

DEGRON score: 0.9971

ASA_SCORE: 76.8571

COIL: 0.82

CONS_SCORE: 0.3221

DSS_SCORE: 0.5513

HELIX: 0.0693

FCONS_SCORE: 0.8885

RIG_SCORE: 0.5328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D954E	TCGA-A6-2685	COAD	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	0.6758
p.D954E	DO10108	COAD	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	0.6758
p.S957L	TCGA-CV-6934	HNSC	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	0.7667
p.S957L	DO15374	HNSC	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	0.7667
p.T948I	TCGA-D7-6822	STAD	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	0.1667
p.T948I	DO38423	STAD	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	0.1667
p.S962Y	TCGA-ER-A19F	SKCM	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	0.2778
p.S962Y	DO37679	SKCM	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	0.2778
p.S955I	TCGA-EY-A215	UCEC	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	0.8453
p.S955I	DO42665	UCEC	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	0.8453
p.S950F	DO229177	LMS	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	0.2222
p.R944C	SIDM00627	Cervical Carcinoma	GDSC	DSGSQYS	DEG_SCF_TRCP1_1	0.0556
p.R944C	ACH-000490	Cervical Cancer	CCLE	DSGSQYS	DEG_SCF_TRCP1_1	0.0556
p.R944C	ACH-001359	Cervical Cancer	CCLE	DSGSQYS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2Q2	FERM domain-containing protein 4A	DEG_SCF_TRCP1_1	954:960	DSGSQYS	BTRC	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons