DegronMD - Q9P2Q2(FRMD4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D954E	TCGA-A6-2685	COAD	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation altering degron motif	0.6758
p.D954E	DO10108	COAD	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation altering degron motif	0.6758
p.P907L	TCGA-CR-5248	HNSC	TCGA	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1667
p.P907L	DO14694	HNSC	ICGC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1667
p.S957L	TCGA-CV-6934	HNSC	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation altering degron motif	0.7667
p.S957L	DO15374	HNSC	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation altering degron motif	0.7667
p.T948I	TCGA-D7-6822	STAD	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.1667
p.T948I	DO38423	STAD	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.1667
p.S962Y	TCGA-ER-A19F	SKCM	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.2778
p.S962Y	DO37679	SKCM	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.2778
p.S955I	TCGA-EY-A215	UCEC	TCGA	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation altering degron motif	0.8453
p.S955I	DO42665	UCEC	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation altering degron motif	0.8453
p.G910D	TCGA-MR-A8JO	LIHC	TCGA	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.0833
p.G910D	DO49714	LIHC	ICGC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.0833
p.S899A	DO222461	BTCA	ICGC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation altering degron motif	0.6477
p.S1007R	DO229028	LICA	ICGC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.7427
p.S1007R	DO229037	LICA	ICGC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.7427
p.S950F	DO229177	LMS	ICGC	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.2222
p.R905W	SIDM01307	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.2222
p.R911C	SIDM02035	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.0556
p.G888D	SIDM02013	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1111
p.G888D	SIDM00433	T-Lymphoblastic Leukemia	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1111
p.G888D	ACH-000795	Leukemia	CCLE	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1111
p.G888D	ACH-000997	Colon/Colorectal Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1111
p.P996Q	SIDM00396	Acute Myeloid Leukemia	GDSC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation rewiring degron network	0.2222
p.P996Q	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation rewiring degron network	0.2222
p.I1000T	SIDM00232	Kidney Carcinoma	GDSC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.7078
p.I1000T	ACH-002168	Kidney Cancer	CCLE	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.7078
p.I1000T	NCC021	kidney	COSMIC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.7078
p.R944C	SIDM00627	Cervical Carcinoma	GDSC	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.0556
p.R944C	ACH-000490	Cervical Cancer	CCLE	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.0556
p.R944C	ACH-001359	Cervical Cancer	CCLE	DSGSQYS	DEG_SCF_TRCP1_1	954:960	Mutation rewiring degron network	0.0556
p.P898S	SIDM00516	Melanoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation altering degron motif	0.6752
p.P898S	SIDM00537	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation altering degron motif	0.6752
p.P898S	ACH-000982	Colon/Colorectal Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation altering degron motif	0.6752
p.P898S	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation altering degron motif	0.6752
p.P898S	ACH-002166	Skin Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation altering degron motif	0.6752
p.P898S	MZ7-mel	skin	COSMIC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation altering degron motif	0.6752
p.G1001E	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.6087
p.G1001E	ACH-002214	Lymphoma	CCLE	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.6087
p.G1001E	BC-1	haematopoietic and lymphoid tissue	COSMIC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation altering degron motif	0.6087
p.S994L	SIDM01609	Endometrial Carcinoma	GDSC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation rewiring degron network	0.1667
p.S994L	SIDM01424	B-Lymphoblastic Leukemia	GDSC	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation rewiring degron network	0.1667
p.S994L	ACH-000782	Leukemia	CCLE	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation rewiring degron network	0.1667
p.S994L	ACH-000972	Endometrial/Uterine Cancer	CCLE	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation rewiring degron network	0.1667
p.S994L	ACH-001735	Leukemia	CCLE	IGATPPSS	DEG_SCF_FBW7_1	1000:1007	Mutation rewiring degron network	0.1667
p.G887D	SIDM01608	Endometrial Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.0833
p.G887D	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.0833
p.D889G	SIDM01770	Gastric Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1389
p.D889N	ACH-000149	Neuroblastoma	CCLE	LTPSRS	DEG_SCF_FBW7_1	896:901	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMD4A

UniProt ID: Q9P2Q2

Entrez ID: 55691

Protein name: FERM domain-containing protein 4A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRMD4A in