DegronMD

Uniprot ID: Q9P2Q2

Source protein: FERM domain-containing protein 4A

Source gene: FRMD4A

Class: DEG_SCF_FBW7_1

Location: 1000:1007

E3 ligase: FBXW7

DEGRON score: 0.9695

ASA_SCORE: 69.975

COIL: 0.9295

CONS_SCORE: 0.2974

DSS_SCORE: 0.7353

HELIX: 0.0271

FCONS_SCORE: 0.8047

RIG_SCORE: 0.5158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1007R	DO229028	LICA	ICGC	IGATPPSS	DEG_SCF_FBW7_1	0.7427
p.S1007R	DO229037	LICA	ICGC	IGATPPSS	DEG_SCF_FBW7_1	0.7427
p.P996Q	SIDM00396	Acute Myeloid Leukemia	GDSC	IGATPPSS	DEG_SCF_FBW7_1	0.2222
p.P996Q	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	IGATPPSS	DEG_SCF_FBW7_1	0.2222
p.I1000T	SIDM00232	Kidney Carcinoma	GDSC	IGATPPSS	DEG_SCF_FBW7_1	0.7078
p.I1000T	ACH-002168	Kidney Cancer	CCLE	IGATPPSS	DEG_SCF_FBW7_1	0.7078
p.I1000T	NCC021	kidney	COSMIC	IGATPPSS	DEG_SCF_FBW7_1	0.7078
p.G1001E	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	IGATPPSS	DEG_SCF_FBW7_1	0.6087
p.G1001E	ACH-002214	Lymphoma	CCLE	IGATPPSS	DEG_SCF_FBW7_1	0.6087
p.G1001E	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	IGATPPSS	DEG_SCF_FBW7_1	0.6087
p.S994L	SIDM01609	Endometrial Carcinoma	GDSC	IGATPPSS	DEG_SCF_FBW7_1	0.1667
p.S994L	SIDM01424	B-Lymphoblastic Leukemia	GDSC	IGATPPSS	DEG_SCF_FBW7_1	0.1667
p.S994L	ACH-000782	Leukemia	CCLE	IGATPPSS	DEG_SCF_FBW7_1	0.1667
p.S994L	ACH-000972	Endometrial/Uterine Cancer	CCLE	IGATPPSS	DEG_SCF_FBW7_1	0.1667
p.S994L	ACH-001735	Leukemia	CCLE	IGATPPSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2Q2	FERM domain-containing protein 4A	DEG_SCF_FBW7_1	1000:1007	IGATPPSS	FBXW7	0.9695	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons