DegronMD

Uniprot ID: Q9P2Q2

Source protein: FERM domain-containing protein 4A

Source gene: FRMD4A

Class: DEG_SCF_FBW7_1

Location: 896:901

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 76.3167

COIL: 0.8538

CONS_SCORE: 0.3862

DSS_SCORE: 0.6806

HELIX: 0.0987

FCONS_SCORE: 0.9982

RIG_SCORE: 0.7227

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P907L	TCGA-CR-5248	HNSC	TCGA	LTPSRS	DEG_SCF_FBW7_1	0.1667
p.P907L	DO14694	HNSC	ICGC	LTPSRS	DEG_SCF_FBW7_1	0.1667
p.G910D	TCGA-MR-A8JO	LIHC	TCGA	LTPSRS	DEG_SCF_FBW7_1	0.0833
p.G910D	DO49714	LIHC	ICGC	LTPSRS	DEG_SCF_FBW7_1	0.0833
p.S899A	DO222461	BTCA	ICGC	LTPSRS	DEG_SCF_FBW7_1	0.6477
p.R905W	SIDM01307	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.2222
p.R911C	SIDM02035	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.0556
p.G888D	SIDM02013	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.1111
p.G888D	SIDM00433	T-Lymphoblastic Leukemia	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.1111
p.G888D	ACH-000795	Leukemia	CCLE	LTPSRS	DEG_SCF_FBW7_1	0.1111
p.G888D	ACH-000997	Colon/Colorectal Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	0.1111
p.P898S	SIDM00516	Melanoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.6752
p.P898S	SIDM00537	Colorectal Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.6752
p.P898S	ACH-000982	Colon/Colorectal Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	0.6752
p.P898S	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	0.6752
p.P898S	ACH-002166	Skin Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	0.6752
p.P898S	MZ7-mel	skin	COSMIC	LTPSRS	DEG_SCF_FBW7_1	0.6752
p.G887D	SIDM01608	Endometrial Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.0833
p.G887D	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPSRS	DEG_SCF_FBW7_1	0.0833
p.D889G	SIDM01770	Gastric Carcinoma	GDSC	LTPSRS	DEG_SCF_FBW7_1	0.1389
p.D889N	ACH-000149	Neuroblastoma	CCLE	LTPSRS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2Q2	FERM domain-containing protein 4A	DEG_SCF_FBW7_1	896:901	LTPSRS	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons