DegronMD

Uniprot ID: Q9H079

Source protein: KATNB1-like protein 1

Source gene: KATNBL1

Class: DEG_SCF_TRCP1_1

Location: 127:133

E3 ligase: BTRC

DEGRON score: 0.8808

ASA_SCORE: 83.5857

COIL: 0.9147

CONS_SCORE: 0.3896

DSS_SCORE: 0.5911

HELIX: 0.0616

FCONS_SCORE: 1.0138

RIG_SCORE: 0.5401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R119Q	TCGA-AN-A046	BRCA	TCGA	DSGSSQT	DEG_SCF_TRCP1_1	0.1111
p.R119Q	DO1285	BRCA	ICGC	DSGSSQT	DEG_SCF_TRCP1_1	0.1111
p.R119Q	SIDM00118	Colorectal Carcinoma	GDSC	DSGSSQT	DEG_SCF_TRCP1_1	0.1111
p.R119Q	ACH-001081	Colon/Colorectal Cancer	CCLE	DSGSSQT	DEG_SCF_TRCP1_1	0.1111
p.R119Q	HCC2998	large_intestine	COSMIC	DSGSSQT	DEG_SCF_TRCP1_1	0.1111
p.T120A	TCGA-CG-5723	STAD	TCGA	DSGSSQT	DEG_SCF_TRCP1_1	0.1389
p.T120A	DO38376	STAD	ICGC	DSGSSQT	DEG_SCF_TRCP1_1	0.1389
p.D127N	TCGA-EE-A29L	SKCM	TCGA	DSGSSQT	DEG_SCF_TRCP1_1	0.6932
p.D127N	DO222599	MELA	ICGC	DSGSSQT	DEG_SCF_TRCP1_1	0.6932
p.D127N	DO37835	SKCM	ICGC	DSGSSQT	DEG_SCF_TRCP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H079	KATNB1-like protein 1	DEG_SCF_TRCP1_1	127:133	DSGSSQT	BTRC	0.8808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons