DegronMD

Uniprot ID: Q13111

Source protein: Chromatin assembly factor 1 subunit A

Source gene: CHAF1A

Class: DEG_SCF_TRCP1_1

Location: 852:858

E3 ligase: BTRC

DEGRON score: 0.7903

ASA_SCORE: 83.0143

COIL: 0.9539

CONS_SCORE: 0.3711

DSS_SCORE: 0.7001

HELIX: 0.0189

FCONS_SCORE: 0.926

RIG_SCORE: 0.5769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I867T	TCGA-A3-3349	KIRC	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	0.0833
p.I867T	DO20614	KIRC	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.0833
p.P857L	TCGA-EB-A5UN	SKCM	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	0.6471
p.P857L	DO47267	SKCM	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.6471
p.P857L	ACH-002069	Bone Cancer	CCLE	DSGSVPS	DEG_SCF_TRCP1_1	0.6471
p.P849T	TCGA-EE-A2GR	SKCM	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	0.25
p.P849T	DO37996	SKCM	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.25
p.P866S	TCGA-EE-A3AA	SKCM	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	0.1111
p.P866S	DO222632	MELA	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.1111
p.P866S	DO37571	SKCM	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.1111
p.S847L	TCGA-IR-A3LI	CESC	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	0.1944
p.S847L	DO44400	CESC	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.1944
p.S844L	TCGA-KC-A7FA	PRAD	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	0.1111
p.S844L	DO219289	PRAD	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.1111
p.D852H	TCGA-N1-A6IA	SARC	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	0.7688
p.D852H	DO220223	SARC	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.7688
p.S855T	DO25189	LUAD	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	0.6005
p.S868L	SIDM02054	Esophageal Carcinoma	GDSC	DSGSVPS	DEG_SCF_TRCP1_1	0.5
p.S868L	SIDM00041	Gastric Carcinoma	GDSC	DSGSVPS	DEG_SCF_TRCP1_1	0.5
p.I867V	SIDM00537	Colorectal Carcinoma	GDSC	DSGSVPS	DEG_SCF_TRCP1_1	0.0833
p.I867V	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGSVPS	DEG_SCF_TRCP1_1	0.0833
p.I867V	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGSVPS	DEG_SCF_TRCP1_1	0.0833
p.I867V	GP5d	large_intestine	COSMIC	DSGSVPS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13111	Chromatin assembly factor 1 subunit A	DEG_SCF_TRCP1_1	852:858	DSGSVPS	BTRC	0.7903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons