DegronMD - Q13111(CHAF1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P303Q	TCGA-19-2624	GBM	TCGA	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0833
p.P303Q	DO14049	GBM	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0833
p.I867T	TCGA-A3-3349	KIRC	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.0833
p.I867T	DO20614	KIRC	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.0833
p.G262C	TCGA-B5-A1MX	UCEC	TCGA	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.25
p.G262C	DO41999	UCEC	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.25
p.P300S	TCGA-BG-A221	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1667
p.P300S	DO42384	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1667
p.E277K	TCGA-CA-6717	COAD	TCGA	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.1389
p.E277K	DO8264	COAD	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.1389
p.E277K	DO230329	COCA	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.1389
p.P784T	TCGA-D3-A2JL	SKCM	TCGA	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation altering degron motif	0.7031
p.P784T	DO47278	SKCM	ICGC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation altering degron motif	0.7031
p.P857L	TCGA-EB-A5UN	SKCM	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation altering degron motif	0.6471
p.P857L	DO47267	SKCM	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation altering degron motif	0.6471
p.P857L	ACH-002069	Bone Cancer	CCLE	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation altering degron motif	0.6471
p.A790S	TCGA-ED-A8O6	LIHC	TCGA	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.25
p.A790S	DO48555	LIHC	ICGC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.25
p.P849T	TCGA-EE-A2GR	SKCM	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.25
p.P849T	DO37996	SKCM	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.25
p.P290L	TCGA-EE-A2MR	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7582
p.P290L	TCGA-HU-A4GN	STAD	TCGA	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7582
p.P290L	DO232761	PBCA	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7582
p.P290L	DO37819	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7582
p.P290L	DO47833	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7582
p.P866S	TCGA-EE-A3AA	SKCM	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.1111
p.P866S	DO222632	MELA	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.1111
p.P866S	DO37571	SKCM	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.1111
p.P276S	TCGA-FW-A3R5	SKCM	TCGA	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.1667
p.P276S	DO37406	SKCM	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.1667
p.R774W	TCGA-IB-7651	PAAD	TCGA	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.1389
p.R774W	DO46657	PAAD	ICGC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.1389
p.S847L	TCGA-IR-A3LI	CESC	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.1944
p.S847L	DO44400	CESC	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.1944
p.S844L	TCGA-KC-A7FA	PRAD	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.1111
p.S844L	DO219289	PRAD	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.1111
p.G771S	TCGA-L5-A8NM	ESCA	TCGA	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.0556
p.D852H	TCGA-N1-A6IA	SARC	TCGA	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation altering degron motif	0.7688
p.D852H	DO220223	SARC	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation altering degron motif	0.7688
p.E788K	TCGA-RP-A6K9	SKCM	TCGA	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.3056
p.E788K	DO219486	SKCM	ICGC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.3056
p.D789V	TCGA-SX-A71S	KIRP	TCGA	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.2778
p.D789V	DO49778	KIRP	ICGC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.2778
p.E297K	DO222697	BTCA	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.25
p.M265L	DO231974	LICA	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation altering degron motif	0.5999
p.E270G	DO228902	LICA	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation altering degron motif	0.7199
p.G771V	DO228948	LICA	ICGC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.0556
p.S775I	DO229036	LICA	ICGC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation blocking phosphorylation signal	0.6111
p.S855T	DO25189	LUAD	ICGC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation altering degron motif	0.6005
p.S283I	DO228291	MALY	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1389
p.S255F	DO222662	MELA	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation blocking phosphorylation signal	0.5
p.P267L	DO222708	MELA	ICGC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation altering degron motif	0.7582
p.S285L	DO218850	SKCA	ICGC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1944
p.S868L	SIDM02054	Esophageal Carcinoma	GDSC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation blocking phosphorylation signal	0.5
p.S868L	SIDM00041	Gastric Carcinoma	GDSC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation blocking phosphorylation signal	0.5
p.S294N	SIDM01090	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7069
p.S294N	ACH-000943	Colon/Colorectal Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7069
p.S294N	RKO	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7069
p.E788D	SIDM00693	Bladder Carcinoma	GDSC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.3056
p.E788D	ACH-000396	Bladder Cancer	CCLE	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.3056
p.E788D	J82	urinary tract	COSMIC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation rewiring degron network	0.3056
p.P303A	SIDM00523	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0833
p.P303A	ACH-000698	Lung Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0833
p.P303A	DMS-53	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0833
p.S280T	SIDM00276	Biliary Tract Carcinoma	GDSC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.0556
p.S280T	SIDM00276	Biliary Tract Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0556
p.S280T	ACH-001858	Bile Duct Cancer	CCLE	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.0556
p.S280T	ACH-001858	Bile Duct Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0556
p.S280T	ACH-002237	Bile Duct Cancer	CCLE	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.0556
p.S280T	ACH-002237	Bile Duct Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0556
p.S280T	ETK-1	biliary tract	COSMIC	MTPESE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.0556
p.S280T	ETK-1	biliary tract	COSMIC	PSSTS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0556
p.I867V	SIDM00537	Colorectal Carcinoma	GDSC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.0833
p.I867V	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.0833
p.I867V	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.0833
p.I867V	GP5d	large intestine	COSMIC	DSGSVPS	DEG_SCF_TRCP1_1	852:858	Mutation rewiring degron network	0.0833
p.S787G	SIDM00217	Colorectal Carcinoma	GDSC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation altering degron motif	0.6993
p.S787G	ACH-000999	Colon/Colorectal Cancer	CCLE	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation altering degron motif	0.6993
p.S787G	SNU-1040	large intestine	COSMIC	LHTPTPS	DEG_SCF_FBW7_1	781:787	Mutation altering degron motif	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHAF1A

UniProt ID: Q13111

Entrez ID: 10036

Protein name: Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHAF1A in