DegronMD

Uniprot ID: Q13111

Source protein: Chromatin assembly factor 1 subunit A

Source gene: CHAF1A

Class: DEG_SCF_FBW7_2

Location: 265:270

E3 ligase: FBXW7

DEGRON score: 0.9866

ASA_SCORE: 93.0333

COIL: 0.7222

CONS_SCORE: 0.3712

DSS_SCORE: 0.7

HELIX: 0.2442

FCONS_SCORE: 1.0557

RIG_SCORE: 0.6641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G262C	TCGA-B5-A1MX	UCEC	TCGA	MTPESE	DEG_SCF_FBW7_2	0.25
p.G262C	DO41999	UCEC	ICGC	MTPESE	DEG_SCF_FBW7_2	0.25
p.E277K	TCGA-CA-6717	COAD	TCGA	MTPESE	DEG_SCF_FBW7_2	0.1389
p.E277K	DO8264	COAD	ICGC	MTPESE	DEG_SCF_FBW7_2	0.1389
p.E277K	DO230329	COCA	ICGC	MTPESE	DEG_SCF_FBW7_2	0.1389
p.P276S	TCGA-FW-A3R5	SKCM	TCGA	MTPESE	DEG_SCF_FBW7_2	0.1667
p.P276S	DO37406	SKCM	ICGC	MTPESE	DEG_SCF_FBW7_2	0.1667
p.M265L	DO231974	LICA	ICGC	MTPESE	DEG_SCF_FBW7_2	0.5999
p.E270G	DO228902	LICA	ICGC	MTPESE	DEG_SCF_FBW7_2	0.7199
p.S255F	DO222662	MELA	ICGC	MTPESE	DEG_SCF_FBW7_2	0.5
p.P267L	DO222708	MELA	ICGC	MTPESE	DEG_SCF_FBW7_2	0.7582
p.S280T	SIDM00276	Biliary Tract Carcinoma	GDSC	MTPESE	DEG_SCF_FBW7_2	0.0556
p.S280T	ACH-001858	Bile Duct Cancer	CCLE	MTPESE	DEG_SCF_FBW7_2	0.0556
p.S280T	ACH-002237	Bile Duct Cancer	CCLE	MTPESE	DEG_SCF_FBW7_2	0.0556
p.S280T	ETK-1	biliary_tract	COSMIC	MTPESE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13111	Chromatin assembly factor 1 subunit A	DEG_SCF_FBW7_2	265:270	MTPESE	FBXW7	0.9866	More...
Q9H195	Mucin-3B	DEG_SCF_FBW7_2	748:753	MTPESE	FBXW7	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons