DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
MTPESE
Uniprot ID:
Q9H195
Source protein:
Mucin-3B
Source gene:
MUC3B
Class:
DEG_SCF_FBW7_2
Location:
748:753
E3 ligase:
FBXW7
DEGRON score:
0.9938
ASA_SCORE:
106.8667
COIL:
0.9217
CONS_SCORE:
0.5334
DSS_SCORE:
0.639
HELIX:
0.0272
FCONS_SCORE:
1.1831
RIG_SCORE:
0.6567
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MTPESE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13111
Chromatin assembly factor 1 subunit A
DEG_SCF_FBW7_2
265:270
MTPESE
FBXW7
0.9866
More...
Q9H195
Mucin-3B
DEG_SCF_FBW7_2
748:753
MTPESE
FBXW7
0.9938
More...