DegronMD

Uniprot ID: Q13111

Source protein: Chromatin assembly factor 1 subunit A

Source gene: CHAF1A

Class: DEG_SCF_FBW7_1

Location: 781:787

E3 ligase: FBXW7

DEGRON score: 0.9471

ASA_SCORE: 81.4143

COIL: 0.8767

CONS_SCORE: 0.3429

DSS_SCORE: 0.6621

HELIX: 0.0473

FCONS_SCORE: 0.87

RIG_SCORE: 0.6529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P784T	TCGA-D3-A2JL	SKCM	TCGA	LHTPTPS	DEG_SCF_FBW7_1	0.7031
p.P784T	DO47278	SKCM	ICGC	LHTPTPS	DEG_SCF_FBW7_1	0.7031
p.A790S	TCGA-ED-A8O6	LIHC	TCGA	LHTPTPS	DEG_SCF_FBW7_1	0.25
p.A790S	DO48555	LIHC	ICGC	LHTPTPS	DEG_SCF_FBW7_1	0.25
p.R774W	TCGA-IB-7651	PAAD	TCGA	LHTPTPS	DEG_SCF_FBW7_1	0.1389
p.R774W	DO46657	PAAD	ICGC	LHTPTPS	DEG_SCF_FBW7_1	0.1389
p.G771S	TCGA-L5-A8NM	ESCA	TCGA	LHTPTPS	DEG_SCF_FBW7_1	0.0556
p.E788K	TCGA-RP-A6K9	SKCM	TCGA	LHTPTPS	DEG_SCF_FBW7_1	0.3056
p.E788K	DO219486	SKCM	ICGC	LHTPTPS	DEG_SCF_FBW7_1	0.3056
p.D789V	TCGA-SX-A71S	KIRP	TCGA	LHTPTPS	DEG_SCF_FBW7_1	0.2778
p.D789V	DO49778	KIRP	ICGC	LHTPTPS	DEG_SCF_FBW7_1	0.2778
p.G771V	DO228948	LICA	ICGC	LHTPTPS	DEG_SCF_FBW7_1	0.0556
p.S775I	DO229036	LICA	ICGC	LHTPTPS	DEG_SCF_FBW7_1	0.6111
p.E788D	SIDM00693	Bladder Carcinoma	GDSC	LHTPTPS	DEG_SCF_FBW7_1	0.3056
p.E788D	ACH-000396	Bladder Cancer	CCLE	LHTPTPS	DEG_SCF_FBW7_1	0.3056
p.E788D	J82	urinary_tract	COSMIC	LHTPTPS	DEG_SCF_FBW7_1	0.3056
p.S787G	SIDM00217	Colorectal Carcinoma	GDSC	LHTPTPS	DEG_SCF_FBW7_1	0.6993
p.S787G	ACH-000999	Colon/Colorectal Cancer	CCLE	LHTPTPS	DEG_SCF_FBW7_1	0.6993
p.S787G	SNU-1040	large_intestine	COSMIC	LHTPTPS	DEG_SCF_FBW7_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13111	Chromatin assembly factor 1 subunit A	DEG_SCF_FBW7_1	781:787	LHTPTPS	FBXW7	0.9471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons