DegronMD

Uniprot ID: Q9ULD6

Source protein: Protein inturned

Source gene: INTU

Class: DEG_SCF_TRCP1_1

Location: 37:43

E3 ligase: BTRC

DEGRON score: 0.9966

ASA_SCORE: 82.0286

COIL: 0.94

CONS_SCORE: 0.3962

DSS_SCORE: 0.6192

HELIX: 0.0387

FCONS_SCORE: 1.1089

RIG_SCORE: 0.5947

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D33H	TCGA-AN-A0FW	BRCA	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	0.2222
p.D33H	DO2825	BRCA	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.2222
p.D50E	TCGA-AP-A051	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	0.1389
p.D50E	DO42673	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.1389
p.L51I	TCGA-AP-A0LM	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	0.1111
p.L51I	DO43306	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.1111
p.D28A	TCGA-B5-A0JY	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	0.0833
p.D28A	DO43041	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.0833
p.Y41C	TCGA-B5-A1MX	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	0.5976
p.Y41C	DO41999	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.5976
p.D47N	TCGA-EM-A1YB	THCA	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	0.2222
p.D47N	DO39143	THCA	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.2222
p.V35A	DO230659	LAML	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	DO231140	LAML	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00434	Plasma Cell Myeloma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00267	Biliary Tract Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00457	Plasma Cell Myeloma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00060	Ovarian Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00492	Glioblastoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00687	Gastric Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00375	Head and Neck Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00489	Oral Cavity Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00988	Kidney Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00368	Small Cell Lung Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM01257	Hepatocellular Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM01612	Endometrial Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00167	Head and Neck Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM00062	Hepatocellular Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM01691	Chronic Myelogenous Leukemia	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM01454	Kidney Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM01587	Bladder Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM01391	Neuroblastoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.V35A	SIDM01442	Glioma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.2778
p.L27M	DO36881	READ	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	0.0556
p.F31Y	SIDM00479	Esophageal Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	0.1667
p.F31Y	OE19	oesophagus	COSMIC	DSGSYSS	DEG_SCF_TRCP1_1	0.1667
p.S36T	ACH-001484	Leukemia	CCLE	DSGSYSS	DEG_SCF_TRCP1_1	0.3056
p.S36T	ACH-001485	Leukemia	CCLE	DSGSYSS	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSYSS

Degron related mutations and impact score

Drug responses associated with INTU mutations

All proteins holding degron of DSGSYSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULD6	Protein inturned	DEG_SCF_TRCP1_1	37:43	DSGSYSS	BTRC	0.9966	More...