DegronMD - Q9ULD6(INTU)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D33H	TCGA-AN-A0FW	BRCA	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2222
p.D33H	DO2825	BRCA	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2222
p.D50E	TCGA-AP-A051	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1389
p.D50E	DO42673	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1389
p.L51I	TCGA-AP-A0LM	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1111
p.L51I	DO43306	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1111
p.D28A	TCGA-B5-A0JY	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0833
p.D28A	DO43041	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0833
p.K703N	TCGA-B5-A11E	UCEC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation substituting flanking lysine	0.3333
p.K703N	DO41644	UCEC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation substituting flanking lysine	0.3333
p.Y41C	TCGA-B5-A1MX	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.5976
p.Y41C	DO41999	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.5976
p.R693K	TCGA-CV-5970	HNSC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation altering degron motif	0.6126
p.R693K	DO14280	HNSC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation altering degron motif	0.6126
p.D47N	TCGA-EM-A1YB	THCA	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2222
p.D47N	DO39143	THCA	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2222
p.R705C	TCGA-EO-A22U	UCEC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	TCGA-FI-A2D0	UCEC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	TCGA-RD-A8NB	STAD	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	TCGA-XK-AAIW	PRAD	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	DO51407	PRAD	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	DO50142	STAD	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	DO43891	UCEC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	DO43755	UCEC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	SIDM00014	Colorectal Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705C	LIM1215	large intestine	COSMIC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.P709L	TCGA-FW-A5DY	SKCM	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.0556
p.P709L	DO47257	SKCM	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.0556
p.V35A	DO230659	LAML	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	DO231140	LAML	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00434	Plasma Cell Myeloma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00267	Biliary Tract Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00457	Plasma Cell Myeloma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00060	Ovarian Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00492	Glioblastoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00687	Gastric Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00375	Head and Neck Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00489	Oral Cavity Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00988	Kidney Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00368	Small Cell Lung Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM01257	Hepatocellular Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM01612	Endometrial Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00167	Head and Neck Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00062	Hepatocellular Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM01691	Chronic Myelogenous Leukemia	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM01454	Kidney Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM01587	Bladder Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM01391	Neuroblastoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM01442	Glioma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.L27M	DO36881	READ	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0556
p.R705H	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.R705H	SIDM00032	Bladder Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.1667
p.Y700N	SIDM00566	Oral Cavity Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.3056
p.Y700N	ACH-001625	Head and Neck Cancer	CCLE	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.3056
p.Y700N	OSC-19	upper aerodigestive tract	COSMIC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.3056
p.F31Y	SIDM00479	Esophageal Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1667
p.F31Y	OE19	oesophagus	COSMIC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1667
p.S36T	ACH-001484	Leukemia	CCLE	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056
p.S36T	ACH-001485	Leukemia	CCLE	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056

Kaplan plot for INTU in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INTU

UniProt ID: Q9ULD6

Entrez ID: 27152

Protein name: Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INTU in