DegronMD - Q9ULD6(INTU)

FUNCTION: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ... View more >>

GO - Biological processes (BP): cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; hair follicle morphogenesis [GO:0031069]; intraciliary transport [GO:0042073]; keratinocyte differentiation [GO:0030216]; limb development [GO:0060173]; motile cilium assembly [GO... View more >>

GO - Molecular function (MF):

GO - Cellular component (CC): cell surface [GO:0009986]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R693K	TCGA-CV-5970	HNSC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation altering degron motif	0.6126
p.R693K	DO14280	HNSC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation altering degron motif	0.6126
p.Y41C	TCGA-B5-A1MX	UCEC	TCGA	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.5976
p.Y41C	DO41999	UCEC	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.5976
p.K703N	TCGA-B5-A11E	UCEC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation substituting flanking lysine	0.3333
p.K703N	DO41644	UCEC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation substituting flanking lysine	0.3333
p.Y700N	SIDM00566	Oral Cavity Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.3056
p.Y700N	ACH-001625	Head and Neck Cancer	CCLE	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.3056
p.Y700N	OSC-19	upper aerodigestive tract	COSMIC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	693:699	Mutation rewiring degron network	0.3056
p.S36T	ACH-001484	Leukemia	CCLE	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056
p.S36T	ACH-001485	Leukemia	CCLE	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056
p.V35A	DO230659	LAML	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	DO231140	LAML	ICGC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00434	Plasma Cell Myeloma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00267	Biliary Tract Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00457	Plasma Cell Myeloma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00060	Ovarian Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00492	Glioblastoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.V35A	SIDM00687	Gastric Carcinoma	GDSC	DSGSYSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 62 entries

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Kaplan plot for INTU in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INTU

UniProt ID: Q9ULD6

Entrez ID: 27152

Protein name: Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INTU in