DegronMD

Uniprot ID: Q9ULD6

Source protein: Protein inturned

Source gene: INTU

Class: LIG_APCC_ABBAyCdc20_2

Location: 693:699

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8804

ASA_SCORE: 90.2429

COIL: 0.7381

CONS_SCORE: 0.3982

DSS_SCORE: 0.4433

HELIX: 0.084

FCONS_SCORE: 1.0609

RIG_SCORE: 0.8105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K703N	TCGA-B5-A11E	UCEC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.3333
p.K703N	DO41644	UCEC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.3333
p.R693K	TCGA-CV-5970	HNSC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.6126
p.R693K	DO14280	HNSC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.6126
p.R705C	TCGA-EO-A22U	UCEC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	TCGA-FI-A2D0	UCEC	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	TCGA-RD-A8NB	STAD	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	TCGA-XK-AAIW	PRAD	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	DO51407	PRAD	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	DO50142	STAD	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	DO43891	UCEC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	DO43755	UCEC	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	SIDM00014	Colorectal Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705C	LIM1215	large_intestine	COSMIC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P709L	TCGA-FW-A5DY	SKCM	TCGA	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P709L	DO47257	SKCM	ICGC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R705H	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R705H	SIDM00032	Bladder Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.Y700N	SIDM00566	Oral Cavity Carcinoma	GDSC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y700N	ACH-001625	Head and Neck Cancer	CCLE	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y700N	OSC-19	upper_aerodigestive_tract	COSMIC	RRTLFGD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULD6	Protein inturned	LIG_APCC_ABBAyCdc20_2	693:699	RRTLFGD	APC,CDC20,FZR1	0.8804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons