DegronMD

Uniprot ID: Q96IZ5

Source protein: RNA-binding protein 41

Source gene: RBM41

Class: DEG_SCF_TRCP1_1

Location: 226:232

E3 ligase: BTRC

DEGRON score: 0.9964

ASA_SCORE: 81.1429

COIL: 0.8876

CONS_SCORE: 0.2619

DSS_SCORE: 0.5501

HELIX: 0.0357

FCONS_SCORE: 1.0817

RIG_SCORE: 0.6164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G228R	TCGA-64-1679	LUAD	TCGA	DSGTAES	DEG_SCF_TRCP1_1	0.7568
p.G228R	DO26200	LUAD	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.7568
p.G228D	TCGA-B5-A3FA	UCEC	TCGA	DSGTAES	DEG_SCF_TRCP1_1	0.7198
p.G228D	DO52402	UCEC	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.7198
p.Q230K	DO48423	BLCA	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.6944
p.L231I	DO229015	LICA	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.7174
p.A221D	DO229037	LICA	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.1944
p.L231R	DO230937	LUSC	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.8428
p.F216C	DO40884	UCEC	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.0556
p.I221T	DO49073	UCEC	ICGC	DSGTAES	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96IZ5	RNA-binding protein 41	DEG_SCF_TRCP1_1	226:232	DSGTAES	BTRC	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons