DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
DSGTDS
Uniprot ID:
Q96K76
Source protein:
Ubiquitin carboxyl-terminal hydrolase 47
Source gene:
USP47
Class:
DEG_SCF_TRCP1_1
Location:
1012:1017
E3 ligase:
BTRC
DEGRON score:
0.9987
ASA_SCORE:
69.6833
COIL:
0.8605
CONS_SCORE:
0.3524
DSS_SCORE:
0.616
HELIX:
0.1212
FCONS_SCORE:
1.0967
RIG_SCORE:
0.6383
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V1007I
TCGA-BS-A0UL
UCEC
TCGA
DSGTDS
DEG_SCF_TRCP1_1
0.1944
p.V1007I
DO41319
UCEC
ICGC
DSGTDS
DEG_SCF_TRCP1_1
0.1944
p.S1006N
TCGA-DI-A1BU
UCEC
TCGA
DSGTDS
DEG_SCF_TRCP1_1
0.1667
p.S1006N
DO42023
UCEC
ICGC
DSGTDS
DEG_SCF_TRCP1_1
0.1667
p.I1024S
TCGA-ND-A4WC
UCS
TCGA
DSGTDS
DEG_SCF_TRCP1_1
0.25
p.R1008Q
DO233929
GACA
ICGC
DSGTDS
DEG_SCF_TRCP1_1
0.6667
p.W1006C
SIDM00216
Colorectal Carcinoma
GDSC
DSGTDS
DEG_SCF_TRCP1_1
0.1667
p.W1006C
ACH-000989
Colon/Colorectal Cancer
CCLE
DSGTDS
DEG_SCF_TRCP1_1
0.1667
p.W1006C
SNU-175
large_intestine
COSMIC
DSGTDS
DEG_SCF_TRCP1_1
0.1667
p.A1009T
SIDM01617
Endometrial Carcinoma
GDSC
DSGTDS
DEG_SCF_TRCP1_1
0.25
p.A1009T
ACH-000994
Endometrial/Uterine Cancer
CCLE
DSGTDS
DEG_SCF_TRCP1_1
0.25
Drug responses associated with USP47 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
SIDM00358
STAD|stomach
p.M533T (No)
GDSC
P22077
73.522
SIDM00680
COREAD|large_intestine
p.R647H (No)
GDSC
P22077
378.62
SIDM00499
PRAD|prostate
p.Y429C (No)
GDSC
P22077
438.46
SIDM00899
PAAD|pancreas
p.G758V (No)
GDSC
P22077
2807.5
SIDM00683
PRAD|prostate
p.F11L (No)
GDSC
P22077
5.6423
SIDM00683
PRAD|prostate
p.F1052S (No)
GDSC
P22077
5.6423
SIDM00683
PRAD|prostate
p.I1177F (No)
GDSC
P22077
5.6423
SIDM00353
UNCLASSIFIED|ovary
p.Q48H (No)
GDSC
P22077
488.63
SIDM00334
UCEC|endometrium
p.K282delK (No)
GDSC
P22077
51.815
SIDM00045
STAD|stomach
p.Q48H (No)
GDSC
P22077
2.9728
SIDM00748
UNCLASSIFIED|lung_NSCLC_large_cell
p.R161fs*4 (No)
GDSC
P22077
28.364
SIDM00212
GBM|glioma
p.D1205H (No)
GDSC
P22077
316.96
SIDM00958
LCML|chronic_myeloid_leukaemia
p.T518A (No)
GDSC
P22077
8.2908
SIDM00154
MESO|mesothelioma
p.F1052C (No)
GDSC
P22077
41.087
SIDM00901
UCEC|endometrium
p.G1033fs*22 (No)
GDSC
P22077
177.44
SIDM01106
SKCM|melanoma
p.T602A (No)
GDSC
P22077
403.32
SIDM00553
LAML|leukemia
p.R1267C (No)
GDSC
P22077
4.6566
SIDM00792
SCLC|lung_small_cell_carcinoma
p.L25I (No)
GDSC
P22077
26.653
SIDM01045
UCEC|endometrium
p.D589E (No)
GDSC
P22077
202.45
SIDM00783
COREAD|large_intestine
p.G1033fs*22 (No)
GDSC
P22077
114.07
SIDM01083
HNSC|head_and_neck
p.E135K (No)
GDSC
P22077
125.78
SIDM00807
BLCA|bladder
p.Y70C (No)
GDSC
P22077
68.394
SIDM00243
UNCLASSIFIED|testis
p.Q48H (No)
GDSC
P22077
6.3865
SIDM00216
COREAD|large_intestine
p.W918C (No)
GDSC
P22077
56.661
SIDM00282
COREAD|large_intestine
p.G453* (No)
GDSC
P22077
34.817
SIDM00150
COREAD|large_intestine
p.S424G (No)
GDSC
P22077
25.415
SIDM00587
UNCLASSIFIED|biliary_tract
p.Q48H (No)
GDSC
P22077
127.42
SIDM01145
STAD|stomach
p.Q48H (No)
GDSC
P22077
72.073
SIDM00422
UNCLASSIFIED|Hodgkin_lymphoma
p.G896* (No)
GDSC
P22077
67.2
SIDM00422
UNCLASSIFIED|Hodgkin_lymphoma
p.T1258I (No)
GDSC
P22077
67.2
SIDM00658
LUAD|lung_NSCLC_adenocarcinoma
p.E826D (No)
GDSC
P22077
165.19
SIDM01175
UNCLASSIFIED|fibrosarcoma
p.N702Y (No)
GDSC
P22077
893.8
SIDM01175
UNCLASSIFIED|fibrosarcoma
p.P1153L (No)
GDSC
P22077
893.8
SIDM00861
UNCLASSIFIED|ovary
p.V141M (No)
GDSC
P22077
82.381
SIDM00342
ALL|lymphoblastic_T_cell_leukaemia
p.V1101A (No)
GDSC
P22077
51.35
SIDM00545
SKCM|melanoma
p.P1178H (No)
GDSC
P22077
137.96
SIDM00727
LUAD|lung_NSCLC_adenocarcinoma
p.S55G (No)
GDSC
P22077
55.142
SIDM01154
ALL|lymphoblastic_T_cell_leukaemia
p.H38Y (No)
GDSC
P22077
50.477
SIDM00855
UNCLASSIFIED|soft_tissue_other
p.R678C (No)
GDSC
P22077
23.14
SIDM01097
UNCLASSIFIED|ewings_sarcoma
p.E385* (No)
GDSC
P22077
103.46
SIDM00491
THCA|thyroid
p.Q48H (No)
GDSC
P22077
64.534
SIDM01060
SKCM|melanoma
p.N395S (No)
GDSC
P22077
13.679
All proteins holding degron of DSGTDS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96K76
Ubiquitin carboxyl-terminal hydrolase 47
DEG_SCF_TRCP1_1
1012:1017
DSGTDS
BTRC
0.9987
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