DegronMD - Q96K76(USP47)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1007I	TCGA-BS-A0UL	UCEC	TCGA	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.1944
p.V1007I	DO41319	UCEC	ICGC	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.1944
p.S1006N	TCGA-DI-A1BU	UCEC	TCGA	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.1667
p.S1006N	DO42023	UCEC	ICGC	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.1667
p.I1024S	TCGA-ND-A4WC	UCS	TCGA	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation substituting flanking lysine	0.25
p.R1008Q	DO233929	GACA	ICGC	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation blocking phosphorylation signal	0.6667
p.W1006C	SIDM00216	Colorectal Carcinoma	GDSC	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.1667
p.W1006C	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.1667
p.W1006C	SNU-175	large intestine	COSMIC	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.1667
p.R1355C	SIDM00553	Acute Myeloid Leukemia	GDSC	LKIYLD	LIG_APCC_ABBA_1	1360:1365	Mutation rewiring degron network	0.1944
p.R1355C	ACH-002262	Leukemia	CCLE	LKIYLD	LIG_APCC_ABBA_1	1360:1365	Mutation rewiring degron network	0.1944
p.R1355C	KY821	haematopoietic and lymphoid tissue	COSMIC	LKIYLD	LIG_APCC_ABBA_1	1360:1365	Mutation rewiring degron network	0.1944
p.A1009T	SIDM01617	Endometrial Carcinoma	GDSC	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.25
p.A1009T	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGTDS	DEG_SCF_TRCP1_1	1012:1017	Mutation rewiring degron network	0.25

Kaplan plot for USP47 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP47

UniProt ID: Q96K76

Entrez ID: 55031

Protein name: Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP47 in