DegronMD

Uniprot ID: Q96K76

Source protein: Ubiquitin carboxyl-terminal hydrolase 47

Source gene: USP47

Class: LIG_APCC_ABBA_1

Location: 1360:1365

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9571

ASA_SCORE: 46.6833

COIL: 0.3467

CONS_SCORE: 0.5334

DSS_SCORE: 0.5091

HELIX: 0.0108

FCONS_SCORE: 1.2243

RIG_SCORE: 0.8057

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1355C	SIDM00553	Acute Myeloid Leukemia	GDSC	LKIYLD	LIG_APCC_ABBA_1	0.1944
p.R1355C	ACH-002262	Leukemia	CCLE	LKIYLD	LIG_APCC_ABBA_1	0.1944
p.R1355C	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	LKIYLD	LIG_APCC_ABBA_1	0.1944

Drug responses associated with USP47 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00358	STAD\|stomach	p.M533T (No)	GDSC	P22077	73.522
SIDM00680	COREAD\|large_intestine	p.R647H (No)	GDSC	P22077	378.62
SIDM00499	PRAD\|prostate	p.Y429C (No)	GDSC	P22077	438.46
SIDM00899	PAAD\|pancreas	p.G758V (No)	GDSC	P22077	2807.5
SIDM00683	PRAD\|prostate	p.F11L (No)	GDSC	P22077	5.6423
SIDM00683	PRAD\|prostate	p.F1052S (No)	GDSC	P22077	5.6423
SIDM00683	PRAD\|prostate	p.I1177F (No)	GDSC	P22077	5.6423
SIDM00353	UNCLASSIFIED\|ovary	p.Q48H (No)	GDSC	P22077	488.63
SIDM00334	UCEC\|endometrium	p.K282delK (No)	GDSC	P22077	51.815
SIDM00045	STAD\|stomach	p.Q48H (No)	GDSC	P22077	2.9728
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R161fs*4 (No)	GDSC	P22077	28.364
SIDM00212	GBM\|glioma	p.D1205H (No)	GDSC	P22077	316.96
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T518A (No)	GDSC	P22077	8.2908
SIDM00154	MESO\|mesothelioma	p.F1052C (No)	GDSC	P22077	41.087
SIDM00901	UCEC\|endometrium	p.G1033fs*22 (No)	GDSC	P22077	177.44
SIDM01106	SKCM\|melanoma	p.T602A (No)	GDSC	P22077	403.32
SIDM00553	LAML\|leukemia	p.R1267C (No)	GDSC	P22077	4.6566
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.L25I (No)	GDSC	P22077	26.653
SIDM01045	UCEC\|endometrium	p.D589E (No)	GDSC	P22077	202.45
SIDM00783	COREAD\|large_intestine	p.G1033fs*22 (No)	GDSC	P22077	114.07
SIDM01083	HNSC\|head_and_neck	p.E135K (No)	GDSC	P22077	125.78
SIDM00807	BLCA\|bladder	p.Y70C (No)	GDSC	P22077	68.394
SIDM00243	UNCLASSIFIED\|testis	p.Q48H (No)	GDSC	P22077	6.3865
SIDM00216	COREAD\|large_intestine	p.W918C (No)	GDSC	P22077	56.661
SIDM00282	COREAD\|large_intestine	p.G453* (No)	GDSC	P22077	34.817
SIDM00150	COREAD\|large_intestine	p.S424G (No)	GDSC	P22077	25.415
SIDM00587	UNCLASSIFIED\|biliary_tract	p.Q48H (No)	GDSC	P22077	127.42
SIDM01145	STAD\|stomach	p.Q48H (No)	GDSC	P22077	72.073
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G896* (No)	GDSC	P22077	67.2
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T1258I (No)	GDSC	P22077	67.2
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.E826D (No)	GDSC	P22077	165.19
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.N702Y (No)	GDSC	P22077	893.8
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1153L (No)	GDSC	P22077	893.8
SIDM00861	UNCLASSIFIED\|ovary	p.V141M (No)	GDSC	P22077	82.381
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.V1101A (No)	GDSC	P22077	51.35
SIDM00545	SKCM\|melanoma	p.P1178H (No)	GDSC	P22077	137.96
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S55G (No)	GDSC	P22077	55.142
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H38Y (No)	GDSC	P22077	50.477
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.R678C (No)	GDSC	P22077	23.14
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.E385* (No)	GDSC	P22077	103.46
SIDM00491	THCA\|thyroid	p.Q48H (No)	GDSC	P22077	64.534
SIDM01060	SKCM\|melanoma	p.N395S (No)	GDSC	P22077	13.679

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKIYLD

Degron related mutations and impact score

Drug responses associated with USP47 mutations

All proteins holding degron of LKIYLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K76	Ubiquitin carboxyl-terminal hydrolase 47	LIG_APCC_ABBA_1	1360:1365	LKIYLD	APC,CDC20,FZR1	0.9571	More...