DegronMD

Uniprot ID: Q09MP3

Source protein: RAD51-associated protein 2

Source gene: RAD51AP2

Class: DEG_SCF_TRCP1_1

Location: 253:258

E3 ligase: BTRC

DEGRON score: 0.9555

ASA_SCORE: 66.0833

COIL: 0.6128

CONS_SCORE: 0.6398

DSS_SCORE: 0.3715

HELIX: 0.0722

FCONS_SCORE: 0.7936

RIG_SCORE: 0.7069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R252T	TCGA-91-6831	LUAD	TCGA	DSGTIS	DEG_SCF_TRCP1_1	0.3056
p.R252T	DO23753	LUAD	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.3056
p.Q261R	TCGA-94-8490	LUSC	TCGA	DSGTIS	DEG_SCF_TRCP1_1	0.25
p.Q261R	DO52021	LUSC	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.25
p.S268I	TCGA-AX-A06F	UCEC	TCGA	DSGTIS	DEG_SCF_TRCP1_1	0.0556
p.S268I	DO41752	UCEC	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.0556
p.S254N	TCGA-E6-A1LX	UCEC	TCGA	DSGTIS	DEG_SCF_TRCP1_1	0.818
p.S254N	DO41020	UCEC	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.818
p.M264I	TCGA-ER-A19E	SKCM	TCGA	DSGTIS	DEG_SCF_TRCP1_1	0.1667
p.M264I	DO47542	SKCM	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.1667
p.R252G	TCGA-GN-A4U9	SKCM	TCGA	DSGTIS	DEG_SCF_TRCP1_1	0.3056
p.R252G	DO50304	SKCM	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.3056
p.P263S	TCGA-Z2-A8RT	SKCM	TCGA	DSGTIS	DEG_SCF_TRCP1_1	0.1944
p.P263S	DO51301	SKCM	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.1944
p.P263S	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	DSGTIS	DEG_SCF_TRCP1_1	0.1944
p.G255S	DO234462	ESAD	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.6993
p.Y250F	DO222749	MELA	ICGC	DSGTIS	DEG_SCF_TRCP1_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09MP3	RAD51-associated protein 2	DEG_SCF_TRCP1_1	253:258	DSGTIS	BTRC	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons