DegronMD - Q09MP3(RAD51AP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R252T	TCGA-91-6831	LUAD	TCGA	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.3056
p.R252T	DO23753	LUAD	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.3056
p.Q261R	TCGA-94-8490	LUSC	TCGA	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.25
p.Q261R	DO52021	LUSC	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.25
p.G1153R	TCGA-AP-A5FX	UCEC	TCGA	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.2778
p.G1153R	DO222472	ESCA	ICGC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.2778
p.G1153R	DO49072	UCEC	ICGC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.2778
p.G1153R	SIDM00945	Colorectal Carcinoma	GDSC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.2778
p.G1153R	ACH-000895	Colon/Colorectal Cancer	CCLE	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.2778
p.G1153R	CL-34	large intestine	COSMIC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.2778
p.S268I	TCGA-AX-A06F	UCEC	TCGA	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.0556
p.S268I	DO41752	UCEC	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.0556
p.S254N	TCGA-E6-A1LX	UCEC	TCGA	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation altering degron motif	0.818
p.S254N	DO41020	UCEC	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation altering degron motif	0.818
p.M264I	TCGA-ER-A19E	SKCM	TCGA	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.1667
p.M264I	DO47542	SKCM	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.1667
p.R252G	TCGA-GN-A4U9	SKCM	TCGA	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.3056
p.R252G	DO50304	SKCM	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.3056
p.P263S	TCGA-Z2-A8RT	SKCM	TCGA	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.1944
p.P263S	DO51301	SKCM	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.1944
p.P263S	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation rewiring degron network	0.1944
p.G255S	DO234462	ESAD	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation altering degron motif	0.6993
p.L1155V	DO233814	GACA	ICGC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation altering degron motif	0.5654
p.K1156N	DO222670	MELA	ICGC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation altering degron motif	0.6918
p.Y250F	DO222749	MELA	ICGC	DSGTIS	DEG_SCF_TRCP1_1	253:258	Mutation blocking phosphorylation signal	0.6944
p.P1145L	DO229462	SKCA	ICGC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.0556
p.M1150I	SIDM00396	Acute Myeloid Leukemia	GDSC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.1944
p.M1150I	SIDM00074	Burkitt's Lymphoma	GDSC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.1944
p.M1150I	ACH-000112	Leukemia	CCLE	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.1944
p.M1150I	ACH-000402	Lymphoma	CCLE	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.1944
p.M1150I	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.1944
p.M1150I	BL-70	haematopoietic and lymphoid tissue	COSMIC	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.1944
p.L1155S	ACH-000436	Myeloma	CCLE	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation altering degron motif	0.6556
p.Y1152C	ACH-001719	Ovarian Cancer	CCLE	LKENF	DEG_APCC_KENBOX_2	1155:1159	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD51AP2

UniProt ID: Q09MP3

Entrez ID: 729475

Protein name: RAD51-associated protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAD51AP2 in