DegronMD

Uniprot ID: Q09MP3

Source protein: RAD51-associated protein 2

Source gene: RAD51AP2

Class: DEG_APCC_KENBOX_2

Location: 1155:1159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9729

ASA_SCORE: 102.08

COIL: 0.703

CONS_SCORE: 0.2853

DSS_SCORE: 0.6031

HELIX: 0.2736

FCONS_SCORE: 0.4828

RIG_SCORE: 0.7939

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1156N	DO222670	MELA	ICGC	LKENF	DEG_APCC_KENBOX_2	0.6918
p.L1155S	ACH-000436	Myeloma	CCLE	LKENF	DEG_APCC_KENBOX_2	0.6556
p.L1155V	DO233814	GACA	ICGC	LKENF	DEG_APCC_KENBOX_2	0.5654
p.G1153R	TCGA-AP-A5FX	UCEC	TCGA	LKENF	DEG_APCC_KENBOX_2	0.2778
p.G1153R	DO222472	ESCA	ICGC	LKENF	DEG_APCC_KENBOX_2	0.2778
p.G1153R	DO49072	UCEC	ICGC	LKENF	DEG_APCC_KENBOX_2	0.2778
p.G1153R	SIDM00945	Colorectal Carcinoma	GDSC	LKENF	DEG_APCC_KENBOX_2	0.2778
p.G1153R	ACH-000895	Colon/Colorectal Cancer	CCLE	LKENF	DEG_APCC_KENBOX_2	0.2778
p.G1153R	CL-34	large_intestine	COSMIC	LKENF	DEG_APCC_KENBOX_2	0.2778
p.Y1152C	ACH-001719	Ovarian Cancer	CCLE	LKENF	DEG_APCC_KENBOX_2	0.25
p.M1150I	SIDM00396	Acute Myeloid Leukemia	GDSC	LKENF	DEG_APCC_KENBOX_2	0.1944
p.M1150I	SIDM00074	Burkitt's Lymphoma	GDSC	LKENF	DEG_APCC_KENBOX_2	0.1944
p.M1150I	ACH-000112	Leukemia	CCLE	LKENF	DEG_APCC_KENBOX_2	0.1944
p.M1150I	ACH-000402	Lymphoma	CCLE	LKENF	DEG_APCC_KENBOX_2	0.1944
p.M1150I	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	LKENF	DEG_APCC_KENBOX_2	0.1944
p.M1150I	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LKENF	DEG_APCC_KENBOX_2	0.1944
p.P1145L	DO229462	SKCA	ICGC	LKENF	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09MP3	RAD51-associated protein 2	DEG_APCC_KENBOX_2	1155:1159	LKENF	APC,CDC20,FZR1	0.9729	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons