DegronMD

Uniprot ID: Q5T5Y3

Source protein: Calmodulin-regulated spectrin-associated protein 1

Source gene: CAMSAP1

Class: DEG_SCF_TRCP1_1

Location: 1381:1387

E3 ligase: BTRC

DEGRON score: 0.8966

ASA_SCORE: 84.2286

COIL: 0.8787

CONS_SCORE: 0.3901

DSS_SCORE: 0.5768

HELIX: 0.0517

FCONS_SCORE: 0.9466

RIG_SCORE: 0.589

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1377Q	TCGA-DG-A2KK	CESC	TCGA	DSGTKCS	DEG_SCF_TRCP1_1	0.2222
p.E1377Q	DO51595	CESC	ICGC	DSGTKCS	DEG_SCF_TRCP1_1	0.2222
p.T1389N	DO229026	LICA	ICGC	DSGTKCS	DEG_SCF_TRCP1_1	0.7222
p.T1389I	DO220898	MELA	ICGC	DSGTKCS	DEG_SCF_TRCP1_1	0.7222
p.S1378L	DO222775	MELA	ICGC	DSGTKCS	DEG_SCF_TRCP1_1	0.6944
p.S1388Y	DO232052	ORCA	ICGC	DSGTKCS	DEG_SCF_TRCP1_1	0.75
p.G1383A	DO229475	SKCA	ICGC	DSGTKCS	DEG_SCF_TRCP1_1	0.754
p.S1378W	SIDM01162	Kidney Carcinoma	GDSC	DSGTKCS	DEG_SCF_TRCP1_1	0.6944
p.S1378W	ACH-001398	Kidney Cancer	CCLE	DSGTKCS	DEG_SCF_TRCP1_1	0.6944
p.C1379Y	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DSGTKCS	DEG_SCF_TRCP1_1	0.2778
p.C1379Y	ACH-001737	Leukemia	CCLE	DSGTKCS	DEG_SCF_TRCP1_1	0.2778
p.C1379Y	ACH-002222	Leukemia	CCLE	DSGTKCS	DEG_SCF_TRCP1_1	0.2778
p.P1372R	RO82-W-1	thyroid	COSMIC	DSGTKCS	DEG_SCF_TRCP1_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_SCF_TRCP1_1	1381:1387	DSGTKCS	BTRC	0.8966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons