DegronMD

Uniprot ID: Q86V48

Source protein: Leucine zipper protein 1

Source gene: LUZP1

Class: DEG_SCF_TRCP1_1

Location: 442:448

E3 ligase: BTRC

DEGRON score: 0.9954

ASA_SCORE: 90.3571

COIL: 0.809

CONS_SCORE: 0.6894

DSS_SCORE: 0.6666

HELIX: 0.1516

FCONS_SCORE: 1.2028

RIG_SCORE: 0.6071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T441A	TCGA-A5-A0G2	UCEC	TCGA	DSGTQET	DEG_SCF_TRCP1_1	0.75
p.T441A	DO41235	UCEC	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.75
p.A432V	TCGA-AM-5821	COAD	TCGA	DSGTQET	DEG_SCF_TRCP1_1	0.0556
p.A432V	DO8240	COAD	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.0556
p.E452K	TCGA-AX-A06F	UCEC	TCGA	DSGTQET	DEG_SCF_TRCP1_1	0.2222
p.E452K	DO41752	UCEC	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.2222
p.A434T	TCGA-EO-A22U	UCEC	TCGA	DSGTQET	DEG_SCF_TRCP1_1	0.1111
p.A434T	DO43755	UCEC	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.1111
p.G458S	DO229010	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.0556
p.G458S	DO229013	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.0556
p.G458S	DO229016	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.0556
p.G458S	DO229003	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.0556
p.G458S	DO229005	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.0556
p.D442V	DO46483	OV	ICGC	DSGTQET	DEG_SCF_TRCP1_1	0.7785
p.S440N	SIDM00111	Glioma	GDSC	DSGTQET	DEG_SCF_TRCP1_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V48	Leucine zipper protein 1	DEG_SCF_TRCP1_1	442:448	DSGTQET	BTRC	0.9954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons