DegronMD - Q86V48(LUZP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R939Q	TCGA-06-5416	GBM	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.R939Q	TCGA-BS-A0UV	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.R939Q	TCGA-EO-A3AV	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.R939Q	DO10880	GBM	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.R939Q	DO52412	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.R939Q	DO42793	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.L668F	TCGA-17-Z026	LUAD	TCGA	ITPEPE	DEG_SCF_FBW7_2	678:683	Mutation rewiring degron network	0.0556
p.P937A	TCGA-73-4659	LUAD	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.25
p.P937A	DO24467	LUAD	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.25
p.T441A	TCGA-A5-A0G2	UCEC	TCGA	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation blocking phosphorylation signal	0.75
p.T441A	DO41235	UCEC	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation blocking phosphorylation signal	0.75
p.R26H	TCGA-A5-A0G2	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.R26H	DO41235	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.R14H	TCGA-AA-A010	COAD	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.L930F	TCGA-AC-A23H	BRCA	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.6981
p.L930F	DO2401	BRCA	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.6981
p.A432V	TCGA-AM-5821	COAD	TCGA	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.0556
p.A432V	DO8240	COAD	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.0556
p.D929Y	TCGA-AP-A059	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.6214
p.D929Y	DO41361	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.6214
p.D28Y	TCGA-AX-A05Z	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222
p.D28Y	DO40884	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222
p.E452K	TCGA-AX-A06F	UCEC	TCGA	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.2222
p.E452K	DO41752	UCEC	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.2222
p.R25H	TCGA-AX-A0J1	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.R25H	DO41199	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.R25C	TCGA-AX-A1C9	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.R25C	DO43098	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.V918A	TCGA-B5-A11E	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1111
p.V918A	DO41644	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1111
p.R26C	TCGA-CM-6674	COAD	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.R26C	DO10092	COAD	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.A434T	TCGA-EO-A22U	UCEC	TCGA	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.1111
p.A434T	DO43755	UCEC	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.1111
p.P936L	TCGA-VD-A8KL	UVM	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.2778
p.P936H	DO222608	BTCA	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.2778
p.G458S	DO229010	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.0556
p.G458S	DO229013	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.0556
p.G458S	DO229016	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.0556
p.G458S	DO229003	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.0556
p.G458S	DO229005	COCA	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation rewiring degron network	0.0556
p.V944M	DO50332	ESAD	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.0556
p.S24R	DO229022	LICA	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6316
p.R921Q	DO50783	LIRI	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.D935Y	DO45283	LIRI	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.3056
p.D442V	DO46483	OV	ICGC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation altering degron motif	0.7785
p.R921W	DO228138	PBCA	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1944
p.E934Q	DO229402	PRAD	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation altering degron motif	0.5633
p.S440N	SIDM00111	Glioma	GDSC	DSGTQET	DEG_SCF_TRCP1_1	442:448	Mutation blocking phosphorylation signal	0.7222
p.L27R	SIDM00596	Endometrial Carcinoma	GDSC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.25
p.L27R	ACH-001517	Endometrial/Uterine Cancer	CCLE	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.25
p.L27R	HEC-1	endometrium	COSMIC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.25
p.T676A	SIDM01450	Gastric Carcinoma	GDSC	ITPEPE	DEG_SCF_FBW7_2	678:683	Mutation rewiring degron network	0.2778
p.T676A	ACH-000898	Gastric Cancer	CCLE	ITPEPE	DEG_SCF_FBW7_2	678:683	Mutation rewiring degron network	0.2778
p.R14C	SIDM01451	Pancreatic Carcinoma	GDSC	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.R14C	ACH-000933	Pancreatic Cancer	CCLE	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.V920A	ACH-000575	Lung Cancer	CCLE	SRRDLKSLE	DEG_APCC_DBOX_1	926:934	Mutation rewiring degron network	0.1667
p.K8R	ACH-001609	Brain Cancer	CCLE	LRFKLQSLS	DEG_APCC_DBOX_1	16:24	Mutation blocking ubiquitination signal	0.5556
p.K672R	ACH-001846	Bile Duct Cancer	CCLE	ITPEPE	DEG_SCF_FBW7_2	678:683	Mutation blocking ubiquitination signal	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LUZP1

UniProt ID: Q86V48

Entrez ID: 7798

Protein name: Leucine zipper protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LUZP1 in