DegronMD

Uniprot ID: Q86V48

Source protein: Leucine zipper protein 1

Source gene: LUZP1

Class: DEG_APCC_DBOX_1

Location: 926:934

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9935

ASA_SCORE: 100.0111

COIL: 0.6791

CONS_SCORE: 0.6754

DSS_SCORE: 0.5083

HELIX: 0.2652

FCONS_SCORE: 1

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R939Q	TCGA-06-5416	GBM	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.R939Q	TCGA-BS-A0UV	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.R939Q	TCGA-EO-A3AV	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.R939Q	DO10880	GBM	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.R939Q	DO52412	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.R939Q	DO42793	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.P937A	TCGA-73-4659	LUAD	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.25
p.P937A	DO24467	LUAD	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.25
p.L930F	TCGA-AC-A23H	BRCA	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.6981
p.L930F	DO2401	BRCA	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.6981
p.D929Y	TCGA-AP-A059	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.6214
p.D929Y	DO41361	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.6214
p.V918A	TCGA-B5-A11E	UCEC	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.1111
p.V918A	DO41644	UCEC	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.1111
p.P936L	TCGA-VD-A8KL	UVM	TCGA	SRRDLKSLE	DEG_APCC_DBOX_1	0.2778
p.P936H	DO222608	BTCA	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.2778
p.V944M	DO50332	ESAD	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.0556
p.R921Q	DO50783	LIRI	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.D935Y	DO45283	LIRI	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.3056
p.R921W	DO228138	PBCA	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.1944
p.E934Q	DO229402	PRAD	ICGC	SRRDLKSLE	DEG_APCC_DBOX_1	0.5633
p.V920A	ACH-000575	Lung Cancer	CCLE	SRRDLKSLE	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V48	Leucine zipper protein 1	DEG_APCC_DBOX_1	926:934	SRRDLKSLE	APC,CDC20,FZR1	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons