DegronMD

Uniprot ID: Q86V48

Source protein: Leucine zipper protein 1

Source gene: LUZP1

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9012

ASA_SCORE: 92.6889

COIL: 0.0653

CONS_SCORE: 0.9413

DSS_SCORE: 0.3101

HELIX: 0.9357

FCONS_SCORE: 1.2276

RIG_SCORE: 0.7741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R26H	TCGA-A5-A0G2	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	0.2778
p.R26H	DO41235	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	0.2778
p.R14H	TCGA-AA-A010	COAD	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	0.2778
p.D28Y	TCGA-AX-A05Z	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	0.2222
p.D28Y	DO40884	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	0.2222
p.R25H	TCGA-AX-A0J1	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	0.3056
p.R25H	DO41199	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	0.3056
p.R25C	TCGA-AX-A1C9	UCEC	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	0.3056
p.R25C	DO43098	UCEC	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	0.3056
p.R26C	TCGA-CM-6674	COAD	TCGA	LRFKLQSLS	DEG_APCC_DBOX_1	0.2778
p.R26C	DO10092	COAD	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	0.2778
p.S24R	DO229022	LICA	ICGC	LRFKLQSLS	DEG_APCC_DBOX_1	0.6316
p.L27R	SIDM00596	Endometrial Carcinoma	GDSC	LRFKLQSLS	DEG_APCC_DBOX_1	0.25
p.L27R	ACH-001517	Endometrial/Uterine Cancer	CCLE	LRFKLQSLS	DEG_APCC_DBOX_1	0.25
p.L27R	HEC-1	endometrium	COSMIC	LRFKLQSLS	DEG_APCC_DBOX_1	0.25
p.R14C	SIDM01451	Pancreatic Carcinoma	GDSC	LRFKLQSLS	DEG_APCC_DBOX_1	0.2778
p.R14C	ACH-000933	Pancreatic Cancer	CCLE	LRFKLQSLS	DEG_APCC_DBOX_1	0.2778
p.K8R	ACH-001609	Brain Cancer	CCLE	LRFKLQSLS	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V48	Leucine zipper protein 1	DEG_APCC_DBOX_1	16:24	LRFKLQSLS	APC,CDC20,FZR1	0.9012	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons