DegronMD

Uniprot ID: Q86V48

Source protein: Leucine zipper protein 1

Source gene: LUZP1

Class: DEG_SCF_FBW7_2

Location: 678:683

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 107.1667

COIL: 0.957

CONS_SCORE: 0.7157

DSS_SCORE: 0.7444

HELIX: 0.0097

FCONS_SCORE: 1.065

RIG_SCORE: 0.6512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L668F	TCGA-17-Z026	LUAD	TCGA	ITPEPE	DEG_SCF_FBW7_2	0.0556
p.T676A	SIDM01450	Gastric Carcinoma	GDSC	ITPEPE	DEG_SCF_FBW7_2	0.2778
p.T676A	ACH-000898	Gastric Cancer	CCLE	ITPEPE	DEG_SCF_FBW7_2	0.2778
p.K672R	ACH-001846	Bile Duct Cancer	CCLE	ITPEPE	DEG_SCF_FBW7_2	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V48	Leucine zipper protein 1	DEG_SCF_FBW7_2	678:683	ITPEPE	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons