DegronMD

Uniprot ID: O15056

Source protein: Synaptojanin-2

Source gene: SYNJ2

Class: DEG_SCF_TRCP1_1

Location: 1438:1443

E3 ligase: BTRC

DEGRON score: 0.9961

ASA_SCORE: 82.5167

COIL: 0.9427

CONS_SCORE: 0.3335

DSS_SCORE: 0.6447

HELIX: 0.0358

FCONS_SCORE: 0.9957

RIG_SCORE: 0.5721

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1438Y	DO229045	LICA	ICGC	DSGTRS	DEG_SCF_TRCP1_1	0.7325
p.G1440E	TCGA-CZ-4866	KIRC	TCGA	DSGTRS	DEG_SCF_TRCP1_1	0.7199
p.G1440E	DO16218	KIRC	ICGC	DSGTRS	DEG_SCF_TRCP1_1	0.7199
p.P1444H	TCGA-EE-A29E	SKCM	TCGA	DSGTRS	DEG_SCF_TRCP1_1	0.3056
p.P1444H	DO37831	SKCM	ICGC	DSGTRS	DEG_SCF_TRCP1_1	0.3056
p.K1445R	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGTRS	DEG_SCF_TRCP1_1	0.2778
p.K1445R	ACH-001639	Leukemia	CCLE	DSGTRS	DEG_SCF_TRCP1_1	0.2778
p.K1445R	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTRS	DEG_SCF_TRCP1_1	0.2778
p.D1435N	TCGA-2G-AAGV	TGCT	TCGA	DSGTRS	DEG_SCF_TRCP1_1	0.25
p.D1447H	ACH-000338	Lymphoma	CCLE	DSGTRS	DEG_SCF_TRCP1_1	0.2222
p.L1430F	SIDM00291	Melanoma	GDSC	DSGTRS	DEG_SCF_TRCP1_1	0.1111
p.L1430F	HMV-II	skin	COSMIC	DSGTRS	DEG_SCF_TRCP1_1	0.1111
p.W1429C	DO229028	LICA	ICGC	DSGTRS	DEG_SCF_TRCP1_1	0.0833

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15056	Synaptojanin-2	DEG_SCF_TRCP1_1	1438:1443	DSGTRS	BTRC	0.9961	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons