DegronMD

Uniprot ID: Q8NFN8

Source protein: Probable G-protein coupled receptor 156

Source gene: GPR156

Class: DEG_SCF_TRCP1_1

Location: 775:781

E3 ligase: BTRC

DEGRON score: 0.9457

ASA_SCORE: 88.0714

COIL: 0.9524

CONS_SCORE: 0.4129

DSS_SCORE: 0.6475

HELIX: 0.0303

FCONS_SCORE: 0.9985

RIG_SCORE: 0.5791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F767V	TCGA-2Y-A9GY	LIHC	TCGA	DSGTSDT	DEG_SCF_TRCP1_1	0.1111
p.F767V	DO219515	LIHC	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	0.1111
p.G787W	TCGA-MI-A75I	LIHC	TCGA	DSGTSDT	DEG_SCF_TRCP1_1	0.1667
p.G787W	DO49712	LIHC	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	0.1667
p.E784D	TCGA-VQ-A8P2	STAD	TCGA	DSGTSDT	DEG_SCF_TRCP1_1	0.25
p.E784D	DO51761	STAD	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	0.25
p.P785T	DO229029	LICA	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	0.2222
p.T778K	DO229006	LICA	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	0.6195
p.T778K	DO229008	LICA	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	0.6195
p.D775N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	DSGTSDT	DEG_SCF_TRCP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFN8	Probable G-protein coupled receptor 156	DEG_SCF_TRCP1_1	775:781	DSGTSDT	BTRC	0.9457	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons