DegronMD - Q8NFN8(GPR156)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F767V	TCGA-2Y-A9GY	LIHC	TCGA	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1111
p.F767V	DO219515	LIHC	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1111
p.R540W	TCGA-A5-A0G2	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1944
p.R540W	DO41235	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1944
p.R538W	TCGA-AN-A0AS	BRCA	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.R538W	TCGA-EE-A29T	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.R538W	DO5228	BRCA	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.R538W	DO37742	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.R538W	SIDM00438	B-Lymphoblastic Leukemia	GDSC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.R538W	ACH-002275	Leukemia	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.R538W	MN-60	haematopoietic and lymphoid tissue	COSMIC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.A562D	TCGA-B5-A0JN	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0833
p.A562D	DO41943	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0833
p.I545T	TCGA-B5-A3FA	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.5966
p.I545T	DO52402	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.5966
p.L558M	TCGA-D3-A8GM	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1944
p.L558M	DO50288	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1944
p.S563F	TCGA-EE-A2GR	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0556
p.S563F	DO37996	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0556
p.R537W	TCGA-EO-A22R	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	TCGA-VQ-A91D	STAD	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	DO51783	STAD	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	DO42713	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	SIDM00502	B-Lymphoblastic Leukemia	GDSC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	SIDM00173	Head and Neck Carcinoma	GDSC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	ACH-000157	Lymphoma	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	ACH-000618	Head and Neck Cancer	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.R537W	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.P560S	TCGA-FW-A3R5	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.P560S	DO37406	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.G787W	TCGA-MI-A75I	LIHC	TCGA	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1667
p.G787W	DO49712	LIHC	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.1667
p.E784D	TCGA-VQ-A8P2	STAD	TCGA	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.25
p.E784D	DO51761	STAD	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.25
p.R540Q	TCGA-VQ-AA6G	STAD	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1944
p.R540Q	DO51801	STAD	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1944
p.E561Q	DO222734	ESCA	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1111
p.P785T	DO229029	LICA	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation rewiring degron network	0.2222
p.T778K	DO229006	LICA	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.6195
p.T778K	DO229008	LICA	ICGC	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.6195
p.R538Q	DO229542	UTCA	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.1389
p.D775N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	DSGTSDT	DEG_SCF_TRCP1_1	775:781	Mutation altering degron motif	0.6932
p.S542R	ACH-001513	Cervical Cancer	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR156

UniProt ID: Q8NFN8

Entrez ID: 165829

Protein name: Probable G-protein coupled receptor 156 (G-protein coupled receptor PGR28) (GABAB-related G-protein coupled receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR156 in