DegronMD

Uniprot ID: Q8NFN8

Source protein: Probable G-protein coupled receptor 156

Source gene: GPR156

Class: DEG_APCC_DBOX_1

Location: 545:553

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6941

ASA_SCORE: 77.1

COIL: 0.1036

CONS_SCORE: 0.519

DSS_SCORE: 0.4538

HELIX: 0.8971

FCONS_SCORE: 1.2891

RIG_SCORE: 0.7833

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R540W	TCGA-A5-A0G2	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1944
p.R540W	DO41235	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1944
p.R538W	TCGA-AN-A0AS	BRCA	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.R538W	TCGA-EE-A29T	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.R538W	DO5228	BRCA	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.R538W	DO37742	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.R538W	SIDM00438	B-Lymphoblastic Leukemia	GDSC	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.R538W	ACH-002275	Leukemia	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.R538W	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.A562D	TCGA-B5-A0JN	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.0833
p.A562D	DO41943	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.0833
p.I545T	TCGA-B5-A3FA	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.5966
p.I545T	DO52402	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.5966
p.L558M	TCGA-D3-A8GM	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1944
p.L558M	DO50288	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1944
p.S563F	TCGA-EE-A2GR	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.0556
p.S563F	DO37996	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.0556
p.R537W	TCGA-EO-A22R	UCEC	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	TCGA-VQ-A91D	STAD	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	DO51783	STAD	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	DO42713	UCEC	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	SIDM00502	B-Lymphoblastic Leukemia	GDSC	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	SIDM00173	Head and Neck Carcinoma	GDSC	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	ACH-000157	Lymphoma	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	ACH-000618	Head and Neck Cancer	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R537W	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.P560S	TCGA-FW-A3R5	SKCM	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.P560S	DO37406	SKCM	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.R540Q	TCGA-VQ-AA6G	STAD	TCGA	IREKLQEVL	DEG_APCC_DBOX_1	0.1944
p.R540Q	DO51801	STAD	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1944
p.E561Q	DO222734	ESCA	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1111
p.R538Q	DO229542	UTCA	ICGC	IREKLQEVL	DEG_APCC_DBOX_1	0.1389
p.S542R	ACH-001513	Cervical Cancer	CCLE	IREKLQEVL	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IREKLQEVL

Degron related mutations and impact score

Drug responses associated with GPR156 mutations

All proteins holding degron of IREKLQEVL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFN8	Probable G-protein coupled receptor 156	DEG_APCC_DBOX_1	545:553	IREKLQEVL	APC,CDC20,FZR1	0.6941	More...