DegronMD

Uniprot ID: P29597

Source protein: Non-receptor tyrosine-protein kinase TYK2

Source gene: TYK2

Class: DEG_SCF_TRCP1_1

Location: 295:301

E3 ligase: BTRC

DEGRON score: 0.9773

ASA_SCORE: 59.4143

COIL: 0.7734

CONS_SCORE: 0.2461

DSS_SCORE: 0.5781

HELIX: 0.0236

FCONS_SCORE: 0.9705

RIG_SCORE: 0.6611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R294L	TCGA-D3-A1QA	SKCM	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	0.3056
p.R294L	TCGA-DK-A2I1	BLCA	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	0.3056
p.R294L	TCGA-FS-A1ZA	SKCM	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	0.3056
p.P305H	TCGA-EE-A2M8	SKCM	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	0.2222
p.R305H	DO8264	COAD	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	0.2222
p.S306C	DO219236	KIRC	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	0.1944
p.G311D	DO43306	UCEC	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	0.0556
p.G311S	DO43891	UCEC	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	0.0556
p.G311S	NB7	autonomic_ganglia	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	0.0556
p.G311S	KM12	large_intestine	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	0.0556
p.A308V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGVAPT	DEG_SCF_TRCP1_1	0.1389
p.A308V	ACH-000920	Leukemia	CCLE	DSGVAPT	DEG_SCF_TRCP1_1	0.1389
p.A308V	ACH-001610	Brain Cancer	CCLE	DSGVAPT	DEG_SCF_TRCP1_1	0.1389
p.A308V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	0.1389
p.G288E	SIDM00567	Other Solid Cancers	GDSC	DSGVAPT	DEG_SCF_TRCP1_1	0.1389
p.G288E	ACH-000776	Brain Cancer	CCLE	DSGVAPT	DEG_SCF_TRCP1_1	0.1389
p.G288E	ONS-76	central_nervous_system	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	0.1389
p.P309S	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29597	Non-receptor tyrosine-protein kinase TYK2	DEG_SCF_TRCP1_1	295:301	DSGVAPT	BTRC	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons