DegronMD - P29597(TYK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R860C	TCGA-14-0787	GBM	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.8301
p.H648Y	TCGA-19-5956	GBM	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.25
p.E636D	TCGA-61-1907	OV	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.3056
p.R864C	TCGA-A5-A0G1	UCEC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.719
p.R864C	TCGA-DF-A2KU	UCEC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.719
p.R633C	TCGA-A5-A1OF	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.2222
p.A652T	TCGA-AP-A1DV	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.1389
p.A652T	TCGA-EO-A22R	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.1389
p.R638Q	TCGA-AX-A2HC	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation altering degron motif	0.7329
p.H872Y	TCGA-BF-A5EO	SKCM	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.1944
p.E852K	TCGA-C5-A1BK	CESC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.1389
p.R864H	TCGA-CD-A4MG	STAD	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.7133
p.R864H	TCGA-FI-A2D0	UCEC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.7133
p.R294L	TCGA-D3-A1QA	SKCM	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.3056
p.R294L	TCGA-DK-A2I1	BLCA	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.3056
p.R294L	TCGA-FS-A1ZA	SKCM	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.3056
p.G271C	TCGA-D3-A2JF	SKCM	TCGA	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.6489
p.P305H	TCGA-EE-A2M8	SKCM	TCGA	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.2222
p.V259G	DO48374	BLCA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.1389
p.E868K	DO2401	BRCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.3056
p.E868K	DO49876	LUAD	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.3056
p.L258V	DO3110	BRCA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation substituting flanking lysine	0.2222
p.E637K	DO6251	CESC	ICGC	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation altering degron motif	0.7022
p.R305H	DO8264	COAD	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.2222
p.L866I	DO227549	COCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.6063
p.GG866GW	DO222492	COCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.7825
p.R263L	DO50326	ESAD	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.25
p.G268R	DO233654	GACA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.7568
p.R257L	DO233823	GACA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.0833
p.E865K	DO12376	GBM	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.7022
p.E874D	DO218992	HNSC	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.1389
p.D856A	DO19370	KIRC	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.25
p.E627D	DO18164	KIRC	ICGC	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.0556
p.S306C	DO219236	KIRC	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1944
p.R257Q	DO230659	LAML	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.0833
p.R633H	DO22596	LGG	ICGC	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.2222
p.H267Q	DO229015	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.7582
p.P256Q	DO229015	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.0556
p.R871S	DO229031	LICA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.2222
p.P273Q	DO229041	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.7035
p.L271M	DO229009	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.711
p.A860D	DO229008	LICA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.7793
p.E865G	DO224610	LUSC	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.7199
p.Y869H	DO46606	OV	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.2778
p.Y869H	MFE-319	endometrium	COSMIC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.2778
p.G855W	DO37410	SKCM	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.2222
p.G265E	DO48618	SKCM	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.3056
p.R873H	DO38663	STAD	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.1667
p.D877G	DO229224	THCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.0556
p.Q276H	DO229232	THCA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.7582
p.G311D	DO43306	UCEC	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.0556
p.G311S	DO43891	UCEC	ICGC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.0556
p.G311S	NB7	autonomic ganglia	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.0556
p.G311S	KM12	large intestine	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.0556
p.V257F	SIDM01265	Plasma Cell Myeloma	GDSC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.0833
p.V257F	ACH-000763	Myeloma	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.0833
p.A308V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1389
p.A308V	ACH-000920	Leukemia	CCLE	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1389
p.A308V	ACH-001610	Brain Cancer	CCLE	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1389
p.A308V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1389
p.Q870K	SIDM00465	Ovarian Carcinoma	GDSC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.25
p.Q870K	ACH-002183	Ovarian Cancer	CCLE	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.25
p.Q870K	OVMIU	ovary	COSMIC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation rewiring degron network	0.25
p.R860H	SIDM00142	Endometrial Carcinoma	GDSC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.8244
p.R860H	ACH-000864	Endometrial/Uterine Cancer	CCLE	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.8244
p.R860H	COLO-684	endometrium	COSMIC	FRTILRDLT	DEG_APCC_DBOX_1	859:867	Mutation altering degron motif	0.8244
p.G288E	SIDM00567	Other Solid Cancers	GDSC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1389
p.G288E	ACH-000776	Brain Cancer	CCLE	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1389
p.G288E	ONS-76	central nervous system	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1389
p.G271S	SIDM01377	Ovarian Carcinoma	GDSC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.5882
p.G271S	ACH-000409	Ovarian Cancer	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.5882
p.R274H	ACH-001322	Sarcoma	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.7133
p.V277M	ACH-002508	Skin Cancer	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation altering degron motif	0.6097
p.P309S	DND-41	haematopoietic and lymphoid tissue	COSMIC	DSGVAPT	DEG_SCF_TRCP1_1	295:301	Mutation rewiring degron network	0.1111
p.P654S	CW-2	large intestine	COSMIC	LRVVLKVLD	DEG_APCC_DBOX_1	637:645	Mutation rewiring degron network	0.0833
p.R263W	SIMA	autonomic ganglia	COSMIC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.25
p.R263W	K5	thyroid	COSMIC	LAPRFGTERVPV	DEG_ODPH_VHL_1	266:277	Mutation rewiring degron network	0.25

Kaplan plot for TYK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TYK2

UniProt ID: P29597

Entrez ID: 7297

Protein name: Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TYK2 in