DegronMD

Uniprot ID: P29597

Source protein: Non-receptor tyrosine-protein kinase TYK2

Source gene: TYK2

Class: DEG_ODPH_VHL_1

Location: 266:277

E3 ligase: VHL

DEGRON score: 0.7835

ASA_SCORE: 55.9333

COIL: 0.439

CONS_SCORE: 0.5028

DSS_SCORE: 0.1215

HELIX: 0.3278

FCONS_SCORE: 1.3454

RIG_SCORE: 0.8115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G271C	TCGA-D3-A2JF	SKCM	TCGA	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.6489
p.V259G	DO48374	BLCA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.1389
p.L258V	DO3110	BRCA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.2222
p.R263L	DO50326	ESAD	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.25
p.G268R	DO233654	GACA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.7568
p.R257L	DO233823	GACA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.0833
p.R257Q	DO230659	LAML	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.0833
p.H267Q	DO229015	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.7582
p.P256Q	DO229015	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.0556
p.P273Q	DO229041	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.7035
p.L271M	DO229009	LICA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.711
p.G265E	DO48618	SKCM	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.3056
p.Q276H	DO229232	THCA	ICGC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.7582
p.V257F	SIDM01265	Plasma Cell Myeloma	GDSC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.0833
p.V257F	ACH-000763	Myeloma	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.0833
p.G271S	SIDM01377	Ovarian Carcinoma	GDSC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.5882
p.G271S	ACH-000409	Ovarian Cancer	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.5882
p.R274H	ACH-001322	Sarcoma	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.7133
p.V277M	ACH-002508	Skin Cancer	CCLE	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.6097
p.R263W	SIMA	autonomic_ganglia	COSMIC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.25
p.R263W	K5	thyroid	COSMIC	LAPRFGTERVPV	DEG_ODPH_VHL_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29597	Non-receptor tyrosine-protein kinase TYK2	DEG_ODPH_VHL_1	266:277	LAPRFGTERVPV	VHL	0.7835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons