DegronMD

Uniprot ID: P29597

Source protein: Non-receptor tyrosine-protein kinase TYK2

Source gene: TYK2

Class: DEG_APCC_DBOX_1

Location: 859:867

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7694

ASA_SCORE: 64.1778

COIL: 0.3829

CONS_SCORE: 0.5926

DSS_SCORE: 0.4329

HELIX: 0.5608

FCONS_SCORE: 1.2843

RIG_SCORE: 0.835

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R860C	TCGA-14-0787	GBM	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	0.8301
p.R864C	TCGA-A5-A0G1	UCEC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	0.719
p.R864C	TCGA-DF-A2KU	UCEC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	0.719
p.H872Y	TCGA-BF-A5EO	SKCM	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	0.1944
p.E852K	TCGA-C5-A1BK	CESC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	0.1389
p.R864H	TCGA-CD-A4MG	STAD	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	0.7133
p.R864H	TCGA-FI-A2D0	UCEC	TCGA	FRTILRDLT	DEG_APCC_DBOX_1	0.7133
p.E868K	DO2401	BRCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.3056
p.E868K	DO49876	LUAD	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.3056
p.L866I	DO227549	COCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.6063
p.GG866GW	DO222492	COCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.7825
p.E865K	DO12376	GBM	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.7022
p.E874D	DO218992	HNSC	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.1389
p.D856A	DO19370	KIRC	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.25
p.R871S	DO229031	LICA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.2222
p.A860D	DO229008	LICA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.7793
p.E865G	DO224610	LUSC	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.7199
p.Y869H	DO46606	OV	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.2778
p.Y869H	MFE-319	endometrium	COSMIC	FRTILRDLT	DEG_APCC_DBOX_1	0.2778
p.G855W	DO37410	SKCM	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.2222
p.R873H	DO38663	STAD	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.1667
p.D877G	DO229224	THCA	ICGC	FRTILRDLT	DEG_APCC_DBOX_1	0.0556
p.Q870K	SIDM00465	Ovarian Carcinoma	GDSC	FRTILRDLT	DEG_APCC_DBOX_1	0.25
p.Q870K	ACH-002183	Ovarian Cancer	CCLE	FRTILRDLT	DEG_APCC_DBOX_1	0.25
p.Q870K	OVMIU	ovary	COSMIC	FRTILRDLT	DEG_APCC_DBOX_1	0.25
p.R860H	SIDM00142	Endometrial Carcinoma	GDSC	FRTILRDLT	DEG_APCC_DBOX_1	0.8244
p.R860H	ACH-000864	Endometrial/Uterine Cancer	CCLE	FRTILRDLT	DEG_APCC_DBOX_1	0.8244
p.R860H	COLO-684	endometrium	COSMIC	FRTILRDLT	DEG_APCC_DBOX_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRTILRDLT

Degron related mutations and impact score

Drug responses associated with TYK2 mutations

All proteins holding degron of FRTILRDLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29597	Non-receptor tyrosine-protein kinase TYK2	DEG_APCC_DBOX_1	859:867	FRTILRDLT	APC,CDC20,FZR1	0.7694	More...