DegronMD

Uniprot ID: P29597

Source protein: Non-receptor tyrosine-protein kinase TYK2

Source gene: TYK2

Class: DEG_APCC_DBOX_1

Location: 637:645

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5725

ASA_SCORE: 22.9667

COIL: 0.1873

CONS_SCORE: 0.5777

DSS_SCORE: 0.3302

HELIX: 0.0067

FCONS_SCORE: 1.7499

RIG_SCORE: 0.8185

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H648Y	TCGA-19-5956	GBM	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	0.25
p.E636D	TCGA-61-1907	OV	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	0.3056
p.R633C	TCGA-A5-A1OF	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	0.2222
p.A652T	TCGA-AP-A1DV	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	0.1389
p.A652T	TCGA-EO-A22R	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	0.1389
p.R638Q	TCGA-AX-A2HC	UCEC	TCGA	LRVVLKVLD	DEG_APCC_DBOX_1	0.7329
p.E637K	DO6251	CESC	ICGC	LRVVLKVLD	DEG_APCC_DBOX_1	0.7022
p.E627D	DO18164	KIRC	ICGC	LRVVLKVLD	DEG_APCC_DBOX_1	0.0556
p.R633H	DO22596	LGG	ICGC	LRVVLKVLD	DEG_APCC_DBOX_1	0.2222
p.P654S	CW-2	large_intestine	COSMIC	LRVVLKVLD	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29597	Non-receptor tyrosine-protein kinase TYK2	DEG_APCC_DBOX_1	637:645	LRVVLKVLD	APC,CDC20,FZR1	0.5725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons