DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: DEG_SCF_TRCP1_1

Location: 1587:1592

E3 ligase: BTRC

DEGRON score: 0.9892

ASA_SCORE: 73.1

COIL: 0.7587

CONS_SCORE: 0.2859

DSS_SCORE: 0.5179

HELIX: 0.1353

FCONS_SCORE: 0.9621

RIG_SCORE: 0.7023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1577L	TCGA-19-5956	GBM	TCGA	DSGVET	DEG_SCF_TRCP1_1	0.0556
p.S1577L	TCGA-EO-A22R	UCEC	TCGA	DSGVET	DEG_SCF_TRCP1_1	0.0556
p.S1577L	DO13863	GBM	ICGC	DSGVET	DEG_SCF_TRCP1_1	0.0556
p.S1577L	DO42713	UCEC	ICGC	DSGVET	DEG_SCF_TRCP1_1	0.0556
p.P1583T	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGVET	DEG_SCF_TRCP1_1	0.2222
p.E1589K	SAT	upper_aerodigestive_tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.7022
p.E1589K	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.7022
p.E1589K	BHY	upper_aerodigestive_tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.7022
p.E1589K	SCH	stomach	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.7022
p.E1589K	TE-6	oesophagus	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.7022
p.E1589K	TC-YIK	cervix	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.7022
p.E1589K	HuO9	bone	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.7022
p.E1585K	SCH	stomach	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.2778
p.E1585K	TE-6	oesophagus	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.2778
p.E1585K	BHY	upper_aerodigestive_tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.2778
p.E1585K	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.2778
p.E1585K	HuO9	bone	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.2778
p.E1585K	TC-YIK	cervix	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.2778
p.E1585K	SAT	upper_aerodigestive_tract	COSMIC	DSGVET	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	DEG_SCF_TRCP1_1	1587:1592	DSGVET	BTRC	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons