DegronMD

Uniprot ID: P19838

Source protein: Nuclear factor NF-kappa-B p105 subunit

Source gene: NFKB1

Class: DEG_SCF_TRCP1_1

Location: 926:932

E3 ligase: BTRC

DEGRON score: 0.986

ASA_SCORE: 60.6429

COIL: 0.584

CONS_SCORE: 0.3359

DSS_SCORE: 0.3485

HELIX: 0.2389

FCONS_SCORE: 1.0554

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D927N	TCGA-A5-A0G9	UCEC	TCGA	DSGVETS	DEG_SCF_TRCP1_1	0.6932
p.R935C	TCGA-EE-A17X	SKCM	TCGA	DSGVETS	DEG_SCF_TRCP1_1	0.3611
p.R934L	DO229029	LICA	ICGC	DSGVETS	DEG_SCF_TRCP1_1	0.2778
p.S921I	DO231104	LUSC	ICGC	DSGVETS	DEG_SCF_TRCP1_1	0.1944
p.R934C	DO37931	SKCM	ICGC	DSGVETS	DEG_SCF_TRCP1_1	0.2778
p.D926N	DO42304	UCEC	ICGC	DSGVETS	DEG_SCF_TRCP1_1	0.6932
p.F939L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGVETS	DEG_SCF_TRCP1_1	0.5833
p.F939L	ACH-000981	Leukemia	CCLE	DSGVETS	DEG_SCF_TRCP1_1	0.5833
p.F939L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.5833
p.E941Q	SIDM00393	Gastric Carcinoma	GDSC	DSGVETS	DEG_SCF_TRCP1_1	0.5278
p.E941Q	ACH-001653	Gastric Cancer	CCLE	DSGVETS	DEG_SCF_TRCP1_1	0.5278
p.E941Q	SK-GT-2	stomach	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.5278
p.V930M	SIDM00596	Endometrial Carcinoma	GDSC	DSGVETS	DEG_SCF_TRCP1_1	0.7208
p.V930M	ACH-000954	Endometrial/Uterine Cancer	CCLE	DSGVETS	DEG_SCF_TRCP1_1	0.7208
p.V930M	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGVETS	DEG_SCF_TRCP1_1	0.7208
p.V930M	HEC-1	endometrium	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.7208
p.E918K	SIDM00220	Ovarian Carcinoma	GDSC	DSGVETS	DEG_SCF_TRCP1_1	0.1111
p.E918K	ACH-000962	Ovarian Cancer	CCLE	DSGVETS	DEG_SCF_TRCP1_1	0.1111
p.E918K	ACH-001145	Ovarian Cancer	CCLE	DSGVETS	DEG_SCF_TRCP1_1	0.1111
p.E918K	OC-314	ovary	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.1111
p.F938L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.1667
p.E940Q	SK-GT-2	stomach	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.1111
p.V929M	HEC-1	endometrium	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.6097
p.E917K	OC-314	ovary	COSMIC	DSGVETS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19838	Nuclear factor NF-kappa-B p105 subunit	DEG_SCF_TRCP1_1	926:932	DSGVETS	BTRC	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVETS

Degron related mutations and impact score

Drug responses associated with NFKB1 mutations

All proteins holding degron of DSGVETS