DegronMD

Uniprot ID: Q86SQ7

Source protein: Serologically defined colon cancer antigen 8

Source gene: SDCCAG8

Class: DEG_SCF_TRCP1_1

Location: 195:201

E3 ligase: BTRC

DEGRON score: 0.9269

ASA_SCORE: 88.5571

COIL: 0.7503

CONS_SCORE: 0.433

DSS_SCORE: 0.5915

HELIX: 0.2331

FCONS_SCORE: 1.0243

RIG_SCORE: 0.6237

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S188F	TCGA-AP-A1DV	UCEC	TCGA	DSGVGET	DEG_SCF_TRCP1_1	0.1389
p.S188F	TCGA-EE-A2MT	SKCM	TCGA	DSGVGET	DEG_SCF_TRCP1_1	0.1389
p.S188F	DO38051	SKCM	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.1389
p.S188F	DO43186	UCEC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.1389
p.S188F	ACH-000084	Leukemia	CCLE	DSGVGET	DEG_SCF_TRCP1_1	0.1389
p.S188Y	TCGA-AX-A05Z	UCEC	TCGA	DSGVGET	DEG_SCF_TRCP1_1	0.1389
p.S188Y	DO40884	UCEC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.1389
p.E200K	TCGA-AZ-4315	COAD	TCGA	DSGVGET	DEG_SCF_TRCP1_1	0.591
p.E200K	DO8842	COAD	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.591
p.S196A	DO6392	CLLE	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.7588
p.T201A	DO222596	COCA	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.7139
p.H186R	DO230999	LUSC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.0833
p.H186R	DO224551	LUSC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	0.0833
p.N187S	SIDM00968	Ovarian Carcinoma	GDSC	DSGVGET	DEG_SCF_TRCP1_1	0.1111
p.N187S	SIDM01215	Ovarian Carcinoma	GDSC	DSGVGET	DEG_SCF_TRCP1_1	0.1111
p.N187S	ACH-000542	Ovarian Cancer	CCLE	DSGVGET	DEG_SCF_TRCP1_1	0.1111
p.N187S	ACH-002140	Ovarian Cancer	CCLE	DSGVGET	DEG_SCF_TRCP1_1	0.1111
p.N187S	Hey	ovary	COSMIC	DSGVGET	DEG_SCF_TRCP1_1	0.1111
p.N187Y	ACH-002024	Colon/Colorectal Cancer	CCLE	DSGVGET	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SQ7	Serologically defined colon cancer antigen 8	DEG_SCF_TRCP1_1	195:201	DSGVGET	BTRC	0.9269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons