DegronMD - Q86SQ7(SDCCAG8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S693I	TCGA-49-6767	LUAD	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1111
p.S188F	TCGA-AP-A1DV	UCEC	TCGA	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1389
p.S188F	TCGA-EE-A2MT	SKCM	TCGA	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1389
p.S188F	DO38051	SKCM	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1389
p.S188F	DO43186	UCEC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1389
p.S188F	ACH-000084	Leukemia	CCLE	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1389
p.S188Y	TCGA-AX-A05Z	UCEC	TCGA	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1389
p.S188Y	DO40884	UCEC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1389
p.E200K	TCGA-AZ-4315	COAD	TCGA	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation altering degron motif	0.591
p.E200K	DO8842	COAD	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation altering degron motif	0.591
p.E697K	TCGA-BF-AAP1	SKCM	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.2222
p.E697K	DO219464	SKCM	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.2222
p.L705V	TCGA-DK-A6AW	BLCA	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.6765
p.L705V	DO48566	BLCA	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.6765
p.R691T	TCGA-FU-A40J	CESC	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.0556
p.R691T	DO44314	CESC	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.0556
p.S196A	DO6392	CLLE	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation altering degron motif	0.7588
p.T201A	DO222596	COCA	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation altering degron motif	0.7139
p.S695L	DO233913	GACA	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1667
p.H186R	DO230999	LUSC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.0833
p.H186R	DO224551	LUSC	ICGC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.0833
p.N187S	SIDM00968	Ovarian Carcinoma	GDSC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1111
p.N187S	SIDM01215	Ovarian Carcinoma	GDSC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1111
p.N187S	ACH-000542	Ovarian Cancer	CCLE	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1111
p.N187S	ACH-002140	Ovarian Cancer	CCLE	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1111
p.N187S	Hey	ovary	COSMIC	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1111
p.S707I	SIDM00807	Bladder Carcinoma	GDSC	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.623
p.S707I	ACH-000905	Bladder Cancer	CCLE	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.623
p.S707I	5637	urinary tract	COSMIC	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.623
p.Q692H	ACH-000886	Lung Cancer	CCLE	LRTQLPSMP	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.0833
p.N187Y	ACH-002024	Colon/Colorectal Cancer	CCLE	DSGVGET	DEG_SCF_TRCP1_1	195:201	Mutation rewiring degron network	0.1111

Kaplan plot for SDCCAG8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SDCCAG8

UniProt ID: Q86SQ7

Entrez ID: 10806

Protein name: Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SDCCAG8 in