DegronMD

Uniprot ID: Q86SQ7

Source protein: Serologically defined colon cancer antigen 8

Source gene: SDCCAG8

Class: DEG_APCC_DBOX_1

Location: 701:709

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6467

ASA_SCORE: 90.7889

COIL: 0.4347

CONS_SCORE: 0.5569

DSS_SCORE: 0.6714

HELIX: 0.559

FCONS_SCORE: 1.0409

RIG_SCORE: 0.6875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S693I	TCGA-49-6767	LUAD	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	0.1111
p.E697K	TCGA-BF-AAP1	SKCM	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	0.2222
p.E697K	DO219464	SKCM	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	0.2222
p.L705V	TCGA-DK-A6AW	BLCA	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	0.6765
p.L705V	DO48566	BLCA	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	0.6765
p.R691T	TCGA-FU-A40J	CESC	TCGA	LRTQLPSMP	DEG_APCC_DBOX_1	0.0556
p.R691T	DO44314	CESC	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	0.0556
p.S695L	DO233913	GACA	ICGC	LRTQLPSMP	DEG_APCC_DBOX_1	0.1667
p.S707I	SIDM00807	Bladder Carcinoma	GDSC	LRTQLPSMP	DEG_APCC_DBOX_1	0.623
p.S707I	ACH-000905	Bladder Cancer	CCLE	LRTQLPSMP	DEG_APCC_DBOX_1	0.623
p.S707I	5637	urinary_tract	COSMIC	LRTQLPSMP	DEG_APCC_DBOX_1	0.623
p.Q692H	ACH-000886	Lung Cancer	CCLE	LRTQLPSMP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SQ7	Serologically defined colon cancer antigen 8	DEG_APCC_DBOX_1	701:709	LRTQLPSMP	APC,CDC20,FZR1	0.6467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons