DegronMD

Uniprot ID: Q96J87

Source protein: CUGBP Elav-like family member 6

Source gene: CELF6

Class: DEG_SCF_TRCP1_1

Location: 24:30

E3 ligase: BTRC

DEGRON score: 0.8045

ASA_SCORE: 65.5143

COIL: 0.8899

CONS_SCORE: 0.2413

DSS_SCORE: 0.5272

HELIX: 0.0426

FCONS_SCORE: 0.9744

RIG_SCORE: 0.6201

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A37T	TCGA-VQ-A8PT	STAD	TCGA	DSGVGMS	DEG_SCF_TRCP1_1	0.1389
p.A37T	DO51776	STAD	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.1389
p.M29I	DO224768	BRCA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.6507
p.F39L	DO224855	BRCA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.0833
p.R37H	DO222574	BTCA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.1389
p.R19Q	DO49887	CESC	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.1944
p.R19Q	DO229030	LICA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.1944
p.A37V	DO233034	GACA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.1389
p.G31R	DO233693	GACA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.3056
p.D34N	DO11854	GBM	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.2222
p.M25I	DO228225	LICA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.7618
p.G28R	DO228359	LICA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.6457
p.L15I	DO228948	LICA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.0833
p.Q30K	DO229015	LICA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.6944
p.L17I	DO229045	LICA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.1389
p.R15Q	DO23244	LINC	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.0833
p.E33K	DO229130	NKTL	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.25
p.P14T	DO229248	THCA	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.V35I	DO41638	UCEC	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.1944
p.G31C	DO41584	UCEC	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.3056
p.G14D	DO41235	UCEC	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.V14F	DO41271	UCEC	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.L26M	DO42472	UCEC	ICGC	DSGVGMS	DEG_SCF_TRCP1_1	0.711
p.M40T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.M40T	SIDM00672	Hepatocellular Carcinoma	GDSC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.M40T	SIDM01090	Colorectal Carcinoma	GDSC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.M40T	SIDM00210	Ovarian Carcinoma	GDSC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.M40T	SIDM00309	Mesothelioma	GDSC	DSGVGMS	DEG_SCF_TRCP1_1	0.0556
p.N33T	ACH-000361	Liver Cancer	CCLE	DSGVGMS	DEG_SCF_TRCP1_1	0.25
p.P36L	ACH-000568	Breast Cancer	CCLE	DSGVGMS	DEG_SCF_TRCP1_1	0.1667
p.P36S	ACH-000568	Breast Cancer	CCLE	DSGVGMS	DEG_SCF_TRCP1_1	0.1667
p.R17L	ACH-001767	Non-Cancerous	CCLE	DSGVGMS	DEG_SCF_TRCP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVGMS

Degron related mutations and impact score

Drug responses associated with CELF6 mutations

All proteins holding degron of DSGVGMS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J87	CUGBP Elav-like family member 6	DEG_SCF_TRCP1_1	24:30	DSGVGMS	BTRC	0.8045	More...