DegronMD

Uniprot ID: Q9Y2L9

Source protein: Leucine-rich repeat and calponin homology domain-containing protein 1

Source gene: LRCH1

Class: DEG_SCF_TRCP1_1

Location: 322:327

E3 ligase: BTRC

DEGRON score: 0.9624

ASA_SCORE: 42.95

COIL: 0.793

CONS_SCORE: 0.3405

DSS_SCORE: 0.6762

HELIX: 0.0613

FCONS_SCORE: 0.9951

RIG_SCORE: 0.5487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V314L	TCGA-22-4595	LUSC	TCGA	DSGVGS	DEG_SCF_TRCP1_1	0.1111
p.V314L	DO26641	LUSC	ICGC	DSGVGS	DEG_SCF_TRCP1_1	0.1111
p.S323L	TCGA-AP-A056	UCEC	TCGA	DSGVGS	DEG_SCF_TRCP1_1	0.7667
p.S323L	DO225346	BRCA	ICGC	DSGVGS	DEG_SCF_TRCP1_1	0.7667
p.S323L	DO43971	UCEC	ICGC	DSGVGS	DEG_SCF_TRCP1_1	0.7667
p.V314M	TCGA-BH-A0AW	BRCA	TCGA	DSGVGS	DEG_SCF_TRCP1_1	0.1111
p.V314M	DO5005	BRCA	ICGC	DSGVGS	DEG_SCF_TRCP1_1	0.1111
p.G326R	TCGA-DK-A2I4	BLCA	TCGA	DSGVGS	DEG_SCF_TRCP1_1	0.6457
p.G326R	DO465	BLCA	ICGC	DSGVGS	DEG_SCF_TRCP1_1	0.6457
p.D328G	DO45083	LINC	ICGC	DSGVGS	DEG_SCF_TRCP1_1	0.3056
p.D322N	SIDM01088	Endometrial Carcinoma	GDSC	DSGVGS	DEG_SCF_TRCP1_1	0.6932
p.D322N	ACH-000965	Endometrial/Uterine Cancer	CCLE	DSGVGS	DEG_SCF_TRCP1_1	0.6932
p.D322N	RL95-2	endometrium	COSMIC	DSGVGS	DEG_SCF_TRCP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2L9	Leucine-rich repeat and calponin homology domain-containing protein 1	DEG_SCF_TRCP1_1	322:327	DSGVGS	BTRC	0.9624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons