DegronMD - Q9Y2L9(LRCH1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V314L	TCGA-22-4595	LUSC	TCGA	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation rewiring degron network	0.1111
p.V314L	DO26641	LUSC	ICGC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation rewiring degron network	0.1111
p.S323L	TCGA-AP-A056	UCEC	TCGA	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.7667
p.S323L	DO225346	BRCA	ICGC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.7667
p.S323L	DO43971	UCEC	ICGC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.7667
p.V314M	TCGA-BH-A0AW	BRCA	TCGA	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation rewiring degron network	0.1111
p.V314M	DO5005	BRCA	ICGC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation rewiring degron network	0.1111
p.S16L	TCGA-BH-A18P	BRCA	TCGA	MATPGSE	DEG_SCF_FBW7_2	1:7	Mutation rewiring degron network	0.0833
p.S16L	TCGA-UC-A7PI	CESC	TCGA	MATPGSE	DEG_SCF_FBW7_2	1:7	Mutation rewiring degron network	0.0833
p.S16L	DO3346	BRCA	ICGC	MATPGSE	DEG_SCF_FBW7_2	1:7	Mutation rewiring degron network	0.0833
p.S16L	DO51616	CESC	ICGC	MATPGSE	DEG_SCF_FBW7_2	1:7	Mutation rewiring degron network	0.0833
p.G326R	TCGA-DK-A2I4	BLCA	TCGA	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.6457
p.G326R	DO465	BLCA	ICGC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.6457
p.D328G	DO45083	LINC	ICGC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation rewiring degron network	0.3056
p.D322N	SIDM01088	Endometrial Carcinoma	GDSC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.6932
p.D322N	ACH-000965	Endometrial/Uterine Cancer	CCLE	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.6932
p.D322N	RL95-2	endometrium	COSMIC	DSGVGS	DEG_SCF_TRCP1_1	322:327	Mutation altering degron motif	0.6932

Kaplan plot for LRCH1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRCH1

UniProt ID: Q9Y2L9

Entrez ID: 23143

Protein name: Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LRCH1 in